التفاصيل البيبلوغرافية
| العنوان: |
Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. |
| المؤلفون: |
Ali, Omar Hasan, Bomze, David, Risch, Lorenz, Brugger, Silvio D, Paprotny, Matthias, Weber, Myriam, Thiel, Sarah, Kern, Lukas, Albrich, Werner C, Kohler, Philipp, Kahlert, Christian R, Vernazza, Pietro, Bühler, Philipp K, Schüpbach, Reto A, Gómez-Mejia, Alejandro, Popa, Alexandra M, Bergthaler, Andreas, Penninger, Josef M, Flatz, Lukas |
| المصدر: |
Clinical Infectious Diseases; 11/1/2021, Vol. 73 Issue 9, pe2869-e2874, 6p |
| مصطلحات موضوعية: |
AUTOANTIBODIES, DIAGNOSTIC reagents & test kits, RESPIRATORY mucosa, COVID-19, IMMUNOGLOBULINS, ANTIPHOSPHOLIPID syndrome, RETROSPECTIVE studies, TERTIARY care, COMPARATIVE studies, SEVERITY of illness index, MEDICAL records, DESCRIPTIVE statistics, STATISTICAL correlation, VIRAL antibodies, DATA analysis software, LONGITUDINAL method |
| مصطلحات جغرافية: |
SWITZERLAND, LIECHTENSTEIN |
| مستخلص: |
Background Severe coronavirus disease 2019 (COVID-19) frequently entails complications that bear similarities to autoimmune diseases. To date, there are little data on possible immunoglobulin (Ig) A–mediated autoimmune responses. Here, we aim to determine whether COVID-19 is associated with a vigorous total IgA response and whether IgA antibodies are associated with complications of severe illness. Since thrombotic events are frequent in severe COVID-19 and resemble hypercoagulation of antiphospholipid syndrome, our approach focused on antiphospholipid antibodies (aPL). Methods In this retrospective cohort study, clinical data and aPL from 64 patients with COVID-19 were compared from 3 independent tertiary hospitals (1 in Liechtenstein, 2 in Switzerland). Samples were collected from 9 April to 1 May 2020. Results Clinical records of 64 patients with COVID-19 were reviewed and divided into a cohort with mild illness (mCOVID; 41%), a discovery cohort with severe illness (sdCOVID; 22%) and a confirmation cohort with severe illness (scCOVID; 38%). Total IgA, IgG, and aPL were measured with clinical diagnostic kits. Severe illness was significantly associated with increased total IgA (sdCOVID, P =.01; scCOVID, P <.001), but not total IgG. Among aPL, both cohorts with severe illness significantly correlated with elevated anticardiolipin IgA (sdCOVID and scCOVID, P <.001), anticardiolipin IgM (sdCOVID, P =.003; scCOVID, P <.001), and anti–beta 2 glycoprotein-1 IgA (sdCOVID and scCOVID, P <.001). Systemic lupus erythematosus was excluded from all patients as a potential confounder. Conclusions Higher total IgA and IgA-aPL were consistently associated with severe illness. These novel data strongly suggest that a vigorous antiviral IgA response, possibly triggered in the bronchial mucosa, induces systemic autoimmunity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
