التفاصيل البيبلوغرافية
| العنوان: |
Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions. |
| المؤلفون: |
Guasch-Ferré, Marta, Yan Zheng, Ruiz-Canela, Miguel, Hruby, Adela, Martínez-González, Miguel A., Clish, Clary B., Corella, Dolores, Estruch, Ramon, Ros, Emilio, Fitó, Montserrat, Dennis, Courtney, Morales-Gil, Isabel M., Arós, Fernando, Fiol, Miquel, Lapetra, José, Serra-Majem, Lluís, Hu, Frank B., Salas-Salvado, Jordi |
| المصدر: |
American Journal of Clinical Nutrition; 6/1/2016, Vol. 103 Issue 6, p1408-1416, 9p, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
CARDIOVASCULAR disease prevention, SMOKING, STROKE risk factors, CARDIOVASCULAR diseases risk factors, CARNITINE, CHI-squared test, CLINICAL trials, CONFIDENCE intervals, HEALTH status indicators, LONGITUDINAL method, MEDICAL cooperation, NUTRITIONAL assessment, PROBABILITY theory, QUESTIONNAIRES, RESEARCH, RESEARCH evaluation, RESEARCH funding, STATISTICAL sampling, T-test (Statistics), BODY mass index, LIFESTYLES, RANDOMIZED controlled trials, PRE-tests & post-tests, PROPORTIONAL hazards models, PHYSICAL activity, DATA analysis software, DESCRIPTIVE statistics, MEDITERRANEAN diet, ODDS ratio |
| مصطلحات جغرافية: |
SPAIN |
| مستخلص: |
Background: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. Objectives: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. Design: We measured plasma acylcarnitines with the use of high-throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected sub-cohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. Results: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. Conclusions: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD. This trial was registered at www.controlled-trials.com as ISRCTN35739639. [ABSTRACT FROM AUTHOR] |
|
Copyright of American Journal of Clinical Nutrition is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder