التفاصيل البيبلوغرافية
| العنوان: |
Association of the interferon-γ gene (CA)n repeat polymorphism with endometriosis. |
| المؤلفون: |
Kim, J. J., Choi, Y. M., Hwang, S. S., Yoon, S. H., Lee, G. H., Chae, S. J., Hwang, K. R., Moon, S. Y. |
| المصدر: |
BJOG: An International Journal of Obstetrics & Gynaecology; Aug2011, Vol. 118 Issue 9, p1061-1066, 6p, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
ENDOMETRIOSIS, GENETIC polymorphisms, GENE frequency, GENOTYPE-environment interaction, POLYMERASE chain reaction, INTERFERONS |
| مصطلحات جغرافية: |
SOUTH Korea |
| مستخلص: |
Objective To investigate whether the interferon-γ (IFN-γ) gene (CA)n repeat polymorphism is associated with susceptibility to endometriosis.Design Case-control study. Setting University Department of Obstetrics and Gynaecology. Population Women with (n = 622) and without (n = 442) endometriosis. Methods Genotyping was performed by fluorescent polymerasechain reaction (PCR) and gene-scan analysis. Main outcome measures Genotype distribution and allele frequency of the dinucleotide (CA)n repeat polymorphism in the IFN-γ gene. Results Seven alleles (12-18 repeats) of the IFN-γ gene (CA)n repeat polymorphism were found. In both patients with endometriosis and controls the most common allele was composed of 13 repeats, followed by an allele of 15 repeats, and then by an allele of 12 repeats. Patients with endometriosis had a significantly higher incidence of genotypes with alleles composed of fewer repeats (12-13 repeats), compared with the controls (92.0 versus 84.4%, respectively, P < 001). Conclusions Our results suggest that the (CA)n repeat polymorphism in the IFN-γ gene may be associated with a risk of endometriosis in the South Korean population. [ABSTRACT FROM AUTHOR] |
|
Copyright of BJOG: An International Journal of Obstetrics & Gynaecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
