التفاصيل البيبلوغرافية
| العنوان: |
Two Outbreak Sources of Influenza A (H7N9) Viruses Have Been Established in China. |
| المؤلفون: |
Dayan Wang1,2, Lei Yang1,2, Wenfei Zhu1,2, Ye Zhang1,2, Shumei Zou1,2, Hong Bo1,2, Rongbao Gao1,2, Jie Dong1,2, Weijuan Huang1,2, Junfeng Guo1,2, Zi Li1,2, Xiang Zhao1,2, Xiaodan Li1,2, Li Xin1,2, Jianfang Zhou1,2, Tao Chen1,2, Libo Dong1,2, Hejiang Wei1,2, Xiyan Li1,2, Liqi Liu1,2 |
| المصدر: |
Journal of Virology. Jun2016, Vol. 90 Issue 12, p5561-5573. 13p. |
| مصطلحات موضوعية: |
*H7N9 Influenza, *DISEASE outbreaks, *PUBLIC health, *GENOTYPES |
| مصطلحات جغرافية: |
PEARL River Delta (China), CHINA |
| مستخلص: |
Due to enzootic infections in poultry and persistent human infections in China, influenza A (H7N9) virus has remained a public health threat. The Yangtze River Delta region, which is located in eastern China, is well recognized as the original source for H7N9 outbreaks. Based on the evolutionary analysis of H7N9 viruses from all three outbreak waves since 2013, we identified the Pearl River Delta region as an additional H7N9 outbreak source. H7N9 viruses are repeatedly introduced from these two sources to the other areas, and the persistent circulation of H7N9 viruses occurs in poultry, causing continuous outbreak waves. Poultry movements may contribute to the geographic expansion of the virus. In addition, the AnH1 genotype, which was predominant during wave 1, was replaced by JS537, JS18828, and AnH1887 genotypes during waves 2 and 3. The establishment of a new source and the continuous evolution of the virus hamper the elimination of H7N9 viruses, thus posing a long-term threat of H7N9 infection in humans. Therefore, both surveillance of H7N9 viruses in humans and poultry and supervision of poultry movements should be strengthened. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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