دورية أكاديمية
Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells
| العنوان: | Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells |
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| المؤلفون: | Zager, Adriano, Brandao, Wesley Nogueira, Margatho, Rafael Oliveira, Gimenes Cruz, Daniel Sanzio, Peron, Jean Pierre, Tufik, Sergio UNIFESP, Andersen, Monica Levy UNIFESP, Moresco, Monica, Pizza, Fabio, Plazzi, Giuseppe, Kornum, Birgitte Rahbek, Palermo-Neto, Joao |
| بيانات النشر: | Pergamon-Elsevier Science Ltd |
| سنة النشر: | 2018 |
| المجموعة: | Universidade Federal de São Paulo (UNIFESP): Repositório Institucional |
| مصطلحات موضوعية: | Modafinil, Peripheral immune cells, Interferon-gamma, Mice, Human, Narcolepsy type 1 |
| جغرافية الموضوع: | Oxford |
| الوصف: | The wake-promoting drug Modafinil has been used for treatment of sleep disorders, such as Narcolepsy, excessive daytime sleepiness and sleep apnea, due to its stimulant action. Despite the known effect of Modafinil on brain neurochemistry, particularly on brain dopamine system, recent evidence support an immunomodulatory role for Modafinil treatment in neuroinflammatory models. Here, we aimed to study the effects of in vitro and in vivo Modafinil treatment on activation, proliferation, cell viability, and cytokine production by immune cells in splenocytes culture from mice. The results show that in vitro treatment with Modafinil increased Interferon (IFN)-gamma, Interleukin (IL)-2 and IL-17 production and CD25 expression by T cells. In turn, in vivo Modafinil treatment enhanced splenocyte production of IFN-gamma, IL-6 and tumor necrosis factor (TNF), and increased the number of IFN-gamma producing cells. Next, we addressed the translational value of the observed effects by testing PBMCs from Narcolepsy type 1 patients that underwent Modafinil treatment. We reported increased number of IFN-gamma producing cells in PBMCs from Narcolepsy type 1 patients following continuous Modafinil treatment, corroborating our animal data. Taken together, our results show, for the first time, a pro-inflammatory action of Modafinil, particularly on IFN-mediated immunity, in mice and in patients with Narcolepsy type 1. The study suggests a novel effect of this drug treatment, which should be taken into consideration when given concomitantly with an ongoing inflammatory or autoimmune process. ; Sao Paulo State Foundation ; CNPq ; AFIP (Associacao Fundo de Incentivo a Pesquisa) ; Univ Sao Paulo, Sch Vet Med, Dept Pathol, Neuroimmunomodulat Res Grp, Sao Paulo, Brazil ; Rigshosp, Mol Sleep Lab, Dept Clin Biochem, Glostrup Res Inst, Glostrup, Denmark ; Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Neuroimmune Interact Lab, Sao Paulo, Brazil ; Univ Fed Sao Paulo, UNIFESP, EPM, Dept Psychobiol, Sao Paulo, Brazil ; Univ Bologna, Dept ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 297-305 |
| اللغة: | English |
| تدمد: | 0278-5846 |
| العلاقة: | Progress In Neuro-Psychopharmacology & Biological Psychiatry; http://dx.doi.org/10.1016/j.pnpbp.2017.09.009Test; Progress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 81, p. 297-305, 2018.; https://repositorio.unifesp.br/handle/11600/54146Test; WOS:000414901100034 |
| DOI: | 10.1016/j.pnpbp.2017.09.009 |
| الإتاحة: | https://doi.org/10.1016/j.pnpbp.2017.09.009Test https://repositorio.unifesp.br/handle/11600/54146Test |
| حقوق: | Acesso restrito |
| رقم الانضمام: | edsbas.C6FFDE9C |
| قاعدة البيانات: | BASE |
| تدمد: | 02785846 |
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| DOI: | 10.1016/j.pnpbp.2017.09.009 |