التفاصيل البيبلوغرافية
| العنوان: |
Comparative whole-genome analysis of diphtheria toxin-producing Corynebacterium ulcerans isolates from sheltered cats in Osaka, Japan. |
| المؤلفون: |
Kaoru UMEDA, Yuji HIRAI |
| المصدر: |
Journal of Veterinary Medical Science; 2023, Vol. 85 Issue 7, p735-738, 4p |
| مصطلحات موضوعية: |
DIPHTHERIA, CORYNEBACTERIUM, DIPHTHERIA toxin, SINGLE nucleotide polymorphisms, CATS |
| مصطلحات جغرافية: |
OSAKA (Japan) |
| مستخلص: |
Diphtheria toxin-producing Corynebacterium ulcerans is a zoonotic pathogen that causes human diphtheria-like symptoms. After performing whole-genome analysis of the five isolates from sheltered cats in Osaka, Japan, we compared them with genome sequences of 25 strains of C. ulcerans from a public database. The five isolates from cats harbored 14 genes encoding possible virulence factors in diphtheria-toxin-producing C. ulcerans. These isolates also had diphtheria toxin gene-encoding prophage in their chromosome, although differences were found in other prophages possession. Whole-genome single-nucleotide polymorphism analysis showed that cats' isolates belonged to ST337 branch, as were strains from Japanese human patients, with 41 or more singlenucleotide polymorphisms variations. High-resolution single-nucleotide polymorphism analysis of C. ulcerans was sufficient to distinguish cats' isolates clearly as not different by conventional genotyping methods. [ABSTRACT FROM AUTHOR] |
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