التفاصيل البيبلوغرافية
| العنوان: |
Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study. |
| المؤلفون: |
Alvarado-Esquivel, Cosme, Ramos-Nevarez, Agar, Guido-Arreola, Carlos Alberto, Cerrillo-Soto, Sandra Margarita, Pérez-Álamos, Alma Rosa, Estrada-Martínez, Sergio, Gutierrez-Martinez, Verónica Dayali, Sifuentes-Alvarez, Antonio, Ramírez-Valles, Eda Guadalupe, Contreras-Cisneros, Edith |
| المصدر: |
BMC Infectious Diseases; 9/18/2019, Vol. 19 Issue 1, pN.PAG-N.PAG, 1p, 2 Charts |
| مصطلحات موضوعية: |
TOXOPLASMA gondii, CASE-control method, THYROID diseases, AGE groups, INFECTION |
| مصطلحات جغرافية: |
DURANGO (Mexico : State), MEXICO |
| مستخلص: |
Background: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction.Methods: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n = 161) or hyperthyroidism (n = 15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti-Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay.Results: Anti-T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR = 0.66; 95% CI: 0.33-1.31; P = 0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR = 0.12; 95% CI: 0.01-0.93; P = 0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P = 0.003).Conclusions: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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