التفاصيل البيبلوغرافية
| العنوان: |
Investigation on the metabolization of parabens and telmisartan in different plants ; Untersuchung zur Metabolisierung von Parabenen und Telmisartan in verschiedenen Pflanzen |
| المؤلفون: |
Lang, Tamara Ulrike |
| سنة النشر: |
2021 |
| المجموعة: |
Johannes Kepler University Linz: JKU |
| مصطلحات موضوعية: |
Umweltanalyse, Pflanzenstoffwechsel, Pharmazeutika, Telmisartan, Paraben, Massenspektrometrie mit Driftrohr-Ionenmobilität, Pflanzenaufnahme, environmental analysis, plant metabolism, pharmaceuticals, drift-tube-ion-mobility mass spectrometry, plant uptake |
| جغرافية الموضوع: |
Linz, UL:TN:AC |
| الوصف: |
Nowadays, a large number of pharmaceutical and personal care products (PPCPs) are used in human as well as in veterinary medicine and introduced into the municipal wastewater system, which are cleaned by wastewater treatment plants (WWTPs). Different kinds of drugs and also PPCPs are found in the effluent of WWTPs, which is introduced into the environment. The present work is dedicated to study the uptake and metabolization of the sartan drug telmisartan (a drug used to treat hypertension) and methyl-, ethyl-, propyl-, butylparaben and 4-hydroxybenzoic acid (substances widely used as preserving agents) by different. The plants were grown hydroponically in a drug-containing cultivation medium and afterwards harvested, extracted and analyzed by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS). Chromatograms, as well as mass spectra were studied. Hence, the determined exact masses of the compounds and their fragmentation patterns in dual stage MS (MS/MS) experiments allowed the tentative identification of possible metabolites. Thereby, eleven potential metabolites of telmisartan could be identified tentatively, in two cases no suggestions for molecular formulas could be made. The parent drug telmisartan was taken up by every plant and could therefore be detected in the respective chromatograms. The knowledge achieved from the treatment of the plants with relatively high concentrations of telmisartan (mg L1 range) was employed to develop an analytical approach allowing to analyze extracts from plants cultivated in actual WWTP effluents. Thereby, next to the parent drug one major metabolite, namely, telmisartan glucose could be identified tentatively. When exposing the plants to the different parabens, neither phase I nor phase II metabolites could be identified due to too low signal intensities. However, all parent substances were found although not in all plants. ; Author Tamara Lang, BSc. ; Abweichender Titel laut Übersetzung der Verfasserin/des Verfassers ; Universität Linz, ... |
| نوع الوثيقة: |
master thesis |
| وصف الملف: |
IX, 47, 17 Seiten; Illustrationen |
| اللغة: |
English |
| العلاقة: |
vignette : https://epub.jku.at/titlepage/urn/urn:nbn:at:at-ubl:1-40708/128Test; eki:OBVAC16136002; urn:nbn:at:at-ubl:1-40708; https://resolver.obvsg.at/urn:nbn:at:at-ubl:1-40708Test; system:AC16136002 |
| الإتاحة: |
https://resolver.obvsg.at/urn:nbn:at:at-ubl:1-40708Test |
| رقم الانضمام: |
edsbas.972EDB9 |
| قاعدة البيانات: |
BASE |
