التفاصيل البيبلوغرافية
| العنوان: |
Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin. |
| المؤلفون: |
Creary, Lisa E., McKenzie, Colin A., Menzel, Stephan, Hanchard, Neil A., Taylor, Veronica, Hambleton, Ian, Spector, Tim D., Forrester, Terrence E., Thein, Swee Lay |
| المصدر: |
British Journal of Haematology; Mar2009, Vol. 144 Issue 6, p954-960, 7p, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
ETHNICITY, CELLS, GENETICS, HEMOGLOBINS, HEMOGLOBINOPATHY, ERYTHROCYTES, GENES |
| مصطلحات جغرافية: |
JAMAICA |
| مستخلص: |
High levels of fetal haemoglobin (HbF) are protective in β-haemoglobinopathies. The proportion of erythrocytes containing HbF (F-cells, FC) was measured in healthy adults of African and Caucasian ancestry to assess the feasibility of localizing genes for the FC trait using admixture mapping. Participants were Afro-Caribbean (AC) blood donors and residents of a rural enclave with a history of recent German admixture (Afro-German, AG) recruited in Jamaica, and Caucasian Europeans recruited in Jamaica and the UK. FC levels were significantly different between groups ( P < 0·001); the geometric mean FC level in the AC sample ( n = 176) was 3·75% [95% confidence interval (CI) 3·36–4·18], AG sample ( n = 631) was 2·77% (95% CI 2·63–2·92), and among Caucasians ( n = 1099) was 3·26% (95% CI 3·13–3·39). After adjustment for age, sex, haemoglobin electrophoresis pattern, and HBG2 genotype, FC levels in the AC group remained significantly different ( P < 0·001) from those in the Caucasian and the AG group but the difference between the Caucasian and AG groups became non-significant ( P = 0·46) despite substantial differences in average ancestry. The data confirm ethnic differences in FC levels and indicate the potential usefulness of these populations for admixture mapping of genes for FC levels. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
