دورية أكاديمية
Progression of cardio-metabolic risk in Chinese women with polycystic ovary syndrome
| العنوان: | Progression of cardio-metabolic risk in Chinese women with polycystic ovary syndrome |
|---|---|
| المساهمون: | Ng, Noel Yat Hey (author.), Ma, Ronald C. W. (thesis advisor.), Chinese University of Hong Kong Graduate School. Division of Medical Sciences. (degree granting institution.) |
| سنة النشر: | 2019 |
| المجموعة: | The Chinese University of Hong Kong: CUHK Digital Repository / 香港中文大學數碼典藏 |
| مصطلحات موضوعية: | Polycystic ovary syndrome--Complications, Cardiovascular system--Diseases--Risk factors, Cardiometabolic Risk Factors |
| جغرافية الموضوع: | Hong Kong |
| الوصف: | Ph.D. ; Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects reproductive aged women. PCOS is characterised by excess androgen levels. It is well established that PCOS is often associated with various metabolic perturbations and multiple cardiometabolic risk factors, such as visceral adiposity, insulin resistance, adverse lipid profile, and type 2 diabetes mellitus (T2DM). However, there is a scarcity of long-term data, especially from non-European populations, regarding the progression of cardiometabolic traits among women with PCOS. ; In order to address some of the current knowledge gaps, in this dissertation, I have examined the progression of glucose intolerance, cardiometabolic risk factors and subclinical atherosclerosis in Chinese women with PCOS. I postulated that women with PCOS would have higher risk of diabetes, subclinical atherosclerosis and cardiovascular diseases. I have compared the overall incidence rate and age-specific incidence rates of diabetes in PCOS women against that of non-PCOS healthy women and the population incidence rate in Hong Kong. Independent predictors of progression of T2DM and carotid intima media thickness (IMT), which was utilised as a surrogate marker for the prediction of subclinical atherosclerosis, were examined respectively in PCOS. Lastly, I hypothesised visceral adiposity strongly contributed to cardiometabolic traits, especially insulin resistance, in PCOS. ; One hundred and ninety-nine Chinese pre-menopausal PCOS women from the Prince of Wales Hospital (PWH) PCOS Registry were previously evaluated as part of a cross-sectional study between 2003 and 2007. They were recalled for detailed clinical and metabolic evaluation at the Diabetes Mellitus & Endocrine Research Centre at the PWH as part of this follow-up study (during 2016-2017). Sonographic assessment with the measurement of mesenteric, preperitoneal and subcutaneous fat thickness; as well as carotid IMT were also conducted in PCOS women. In the long-term prospective studies, ... |
| نوع الوثيقة: | text |
| وصف الملف: | electronic resource; remote; 1 online resource (xxii, 233 leaves) : illustrations (some color); computer; online resource |
| اللغة: | English Chinese |
| العلاقة: | cuhk:2327295; local: ETD920200948; local: AAI27662602; local: 991039842704003407; https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991039842704003407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_USTest; https://repository.lib.cuhk.edu.hk/en/item/cuhk-2327295Test |
| الإتاحة: | https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991039842704003407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_USTest https://repository.lib.cuhk.edu.hk/en/item/cuhk-2327295Test |
| حقوق: | Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-NoDerivatives 4.0 International" License (http://creativecommons.org/licenses/by-nc-nd/4.0Test/) |
| رقم الانضمام: | edsbas.1C57D58A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |