التفاصيل البيبلوغرافية
| العنوان: |
Emergence of serogroup C meningococcal disease associated with a high mortality rate in Hefei, China. |
| المؤلفون: |
Xi-Hai Xu1, Ying Ye1, Li-Fen Hu2,3, Yu-Hui Jin4, Qin-Qin Jiang4, Jia-Bin Li1,2 jiabinli948@163.com |
| المصدر: |
BMC Infectious Diseases. 2012, Vol. 12 Issue 1, p205-212. 8p. 3 Charts, 2 Graphs. |
| مصطلحات موضوعية: |
*NEISSERIA meningitidis, *GEL electrophoresis, *UNIVARIATE analysis |
| مصطلحات جغرافية: |
HEFEI Shi (China), CHINA |
| مستخلص: |
Background: Neisseria meningitidis serogroup C has emerged as a cause of epidemic disease in Hefei. The establishment of serogroup C as the predominant cause of endemic disease has not been described. Methods: We conducted national laboratory-based surveillance for invasive meningococcal disease during 2000-2010. Isolates were characterized by pulsed-field gel electrophoresis and multilocus sequence typing. Results: A total of 845 cases of invasive meningococcal disease were reported. The incidence increased from 1.25 cases per 100,000 population in 2000 to 3.14 cases per 100,000 in 2003 (p < 0.001), and peaked at 8.43 cases per 100,000 in 2005. The increase was mainly the result of an increase in the incidence of serogroup C disease. Serogroup C disease increased from 2/23 (9%) meningococcal cases and 0.11 cases per 100,000 in 2000 to 33/58 (57%) cases and 1.76 cases per 100,000 in 2003 (p < 0.01). Patients infected with serogroup C had serious complications more frequently than those infected with other serogroups. Specifically, 161/493 (32.7%) cases infected with serogroup C had at least one complication. The case-fatality rate of serogroup C meningitis was 11.4%, significantly higher than for serogroup A meningitis (5.3%, p = 0.021). Among patients with meningococcal disease, factors associated with death in univariate analysis were age of 15-24 years, infection with serogroup C, and meningococcemia. Conclusions: The incidence of meningococcal disease has substantially increased and serogroup C has become endemic in Hefei. The serogroup C strain has caused more severe disease than the previously predominant serogroup A strain. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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