التفاصيل البيبلوغرافية
| العنوان: |
Real-world analysis of patient characteristics, treatment outcomes, and healthcare resource utilization across Europe in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation who received lenalidomide- or bortezomib-based regimens |
| المؤلفون: |
Zamagni, Elena, Dhanasiri, Sujith, Ghale, Arun, Moore, Adam, Roussel, Murielle |
| المصدر: |
Leukemia & Lymphoma; Oct 2021, Vol. 62 Issue 10, p2492-2501, 10p |
| مصطلحات موضوعية: |
STEM cell transplantation, MULTIPLE myeloma, DIAGNOSIS, TREATMENT effectiveness, LENALIDOMIDE, WATCHFUL waiting |
| مصطلحات جغرافية: |
EUROPE |
| مستخلص: |
We aimed to compare real-world outcomes, resource use, and costs for patients with newly diagnosed multiple myeloma (NDMM) treated with continuous first-line (1 L) lenalidomide or fixed bortezomib in Europe. We performed a multicenter, retrospective, observational chart review of transplant-ineligible NDMM patients across 7 countries. Of 453 eligible patients, 220 received 1 L lenalidomide-based regimens; 105 (47.7%) received second-line (2 L) treatment, of which 50 (47.6%) received 2 L bortezomib. 233 patients received 1 L bortezomib-based regimens; 142 (60.9%) had 2 L treatment, of which 104 (73.2%) received 2 L lenalidomide. Patients receiving 1 L lenalidomide-based regimens had better progression-free survival than patients receiving 1 L bortezomib-based regimens (p =.002) and a longer time to 2 L or third-line treatment (both p <.05). Total treatment-associated monthly costs for patients receiving 1 L lenalidomide-based regimens (n = 171, €2,268.55) were significantly greater than for 1 L bortezomib-based regimens (n = 188, €1,724.77) (p <.001) over the follow-up period (median, 38.7 months). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
