التفاصيل البيبلوغرافية
| العنوان: |
Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view. |
| المؤلفون: |
Ruggieri, Matias, Berini, Carolina, Ducasa, Nicolas, Malkovsky, Miroslav, Fisch, Paul, Biglione, Mirna |
| المصدر: |
PLoS ONE; 5/28/2019, Vol. 14 Issue 5, p1-9, 9p |
| مصطلحات موضوعية: |
HTLV-I, HTLV, ONCOLOGY, INFECTION, T-cell lymphoma |
| مصطلحات جغرافية: |
GERMANY, EUROPE |
| الشركة/الكيان: |
EUROPEAN Union |
| مستخلص: |
Human T-cell lymphotropic virus (HTLV) belongs to a larger group of primate T-cell lymphotropic viruses (PTLVs) within the family Retroviridae. It is estimated that 10 to 20 million people worldwide may be infected with HTLV-1. Although most of them are asymptomatic, around 5% of infected individuals may develop either HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) or Adult T-cell Leukaemia/Lymphoma (ATLL). Public Health authorities in many countries have implemented routine blood-donor tests for HTLV-specific antibodies; but this is not the case for Germany since the reported prevalence is very low (7/100,000). With the aim to evaluate retrospectively the presence of HTLV-1 among oncology patients in this country, samples stored at the Universitätsklinikum Freiburg, were analyzed. For this purpose, two different nested-PCR (n-PCR) protocols have been modified and set up for HTLV-1 detection. One positive case was detected by n-PCR among 406 samples (0,25%) in a period of 5 years (2008–2012) corresponding to a T-Cell Lymphoma. Despite the low prevalence, this virus is circulating in Germany, probably due to the increasing numbers of immigrants in these last years. Physicians should consider HTLV-1 infection and suspect it taking in account the ethnic and relation to endemic regions regardless the patient's residence. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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