دورية أكاديمية
Neonatal outcomes of extremely preterm twins by sex pairing: an international cohort study.
| العنوان: | Neonatal outcomes of extremely preterm twins by sex pairing: an international cohort study. |
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| المؤلفون: | Gagliardi, L, Rusconi, F, Reichman, B, Adams, M, Modi, N, Lehtonen, L, Kusuda, S, Vento, M, Darlow, BA, Bassler, D, Isayama, T, Norman, M, Håkansson, S, Lee, SK, Lui, K, Yang, J, Shah, P, International Network for Evaluating Outcomes of Neonates (iNeo) Investigators |
| المصدر: | 24 ; 17 |
| بيانات النشر: | BMJ Publishing Group |
| سنة النشر: | 2020 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | mortality, multiple births, neonatology, outcomes research, twins, Bronchopulmonary Dysplasia, Cerebral Intraventricular Hemorrhage, Developed Countries, Female, Gestational Age, Hospital Mortality, Humans, Infant, Extremely Premature, Newborn, Premature, Diseases, Very Low Birth Weight, Leukomalacia, Periventricular, Male, Retinopathy of Prematurity, Retrospective Studies, Severity of Illness Index, Sex Factors, International Network for Evaluating Outcomes of Neonates (iNeo) Investigators |
| جغرافية الموضوع: | England |
| الوصف: | OBJECTIVE: Infant boys have worse outcomes than girls. In twins, the 'male disadvantage' has been reported to extend to female co-twins via a 'masculinising' effect. We studied the association between sex pairing and neonatal outcomes in extremely preterm twins. DESIGN: Retrospective cohort study SETTING: Eleven countries participating in the International Network for Evaluating Outcomes of Neonates. PATIENTS: Liveborn twins admitted at 23-29 weeks' gestation in 2007-2015. MAIN OUTCOME MEASURES: We examined in-hospital mortality, grades 3/4 intraventricular haemorrhage or cystic periventricular leukomalacia (IVH/PVL), bronchopulmonary dysplasia (BPD), retinopathy of prematurity requiring treatment and a composite outcome (mortality or any of the outcomes above). RESULTS: Among 20 924 twins, 38% were from male-male pairs, 32% were from female-female pairs and 30% were sex discordant. We had no information on chorionicity. Girls with a male co-twin had lower odds of mortality, IVH/PVL and the composite outcome than girl-girl pairs (reference group): adjusted OR (aOR) (95% CI) 0.79 (0.68 to 0.92), 0.83 (0.72 to 0.96) and 0.88 (0.79 to 0.98), respectively. Boys with a female co-twin also had lower odds of mortality: aOR 0.86 (0.74 to 0.99). Boys from male-male pairs had highest odds of BPD and composite outcome: aOR 1.38 (1.24 to 1.52) and 1.27 (1.16 to 1.39), respectively. CONCLUSIONS: Sex-related disparities in outcomes exist in extremely preterm twins, with girls having lower risks than boys and opposite-sex pairs having lower risks than same-sex pairs. Our results may help clinicians in assessing risk in this large segment of extremely preterm infants. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1359-2998 |
| العلاقة: | Archives of Disease in Childhood: Fetal and Neonatal Edition; http://hdl.handle.net/10044/1/80857Test |
| DOI: | 10.1136/archdischild-2020-318832 |
| الإتاحة: | https://doi.org/10.1136/archdischild-2020-318832Test http://hdl.handle.net/10044/1/80857Test |
| حقوق: | © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. This article has been accepted for publication in Archives of Disease in Childhood - Fetal and Neonatal Edition following peer review. The definitive copyedited, typeset version Gagliardi L, Rusconi F, Reichman B the International Network for Evaluating Outcomes of Neonates (iNeo) Investigators, et alNeonatal outcomes of extremely preterm twins by sex pairing: an international cohort studyArchives of Disease in Childhood - Fetal and Neonatal Edition 2021 is available online at: http://dx.doi.org/10.1136/archdischild-2020-318832Test |
| رقم الانضمام: | edsbas.C4E03DE9 |
| قاعدة البيانات: | BASE |
| تدمد: | 13592998 |
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| DOI: | 10.1136/archdischild-2020-318832 |