التفاصيل البيبلوغرافية
| العنوان: |
Diabetes Mellitus and Impaired Glucose Tolerance Are Associated with Poor Pulmonary Function in Adults with Cystic Fibrosis. |
| المؤلفون: |
Adler, Amanda I., Gunn, Elaine, Haworth, Charles S., Shine, Brian S., Diana, Bilton |
| المصدر: |
Diabetes; Jun2007 Supplement 1, Vol. 56, pA267-A267, 1/4p |
| مصطلحات موضوعية: |
DIABETES, BLOOD sugar, LUNG diseases, CYSTIC fibrosis, PEOPLE with diabetes |
| مصطلحات جغرافية: |
EAST of England |
| مستخلص: |
In adults with cystic fibrosis (CF), pulmonary complications predominate and are highly associated with mortality. Because diabetes and impaired glucose tolerance (DM + IGT) are highly prevalent in this population, we evaluated the association between DM + IGT and pulmonary function. We performed a cross-sectional study among adults with CF in Eastern England identified through a clinic in 2005 providing population-based care to adults with CF, including annual oral glucose tolerance tests (OGTT) to those without diabetes. Of 157 individuals, 6 without a history of diabetes or an OGTT were excluded. Subjects included 55 individuals with DM, 18 with IGT, and 78 with normal glucose tolerance (NGT) as defined by history or by OGGT using ADA criteria. Pulmonary function was defined as forced expiratory volume at 1 second (FEV1) and forced vital capacity (FVC), both expressed as percentage predicted for age and sex. Linear regression was used to model the association between DM-IGT relative to NGT and FEV 1 or FVC controlling for age, sex, body mass index (BMI), and other risk factors for poor pulmonary function. The mean age was 26 (range 16-61) years, BMI 21.4 (range 15.8 - 31.8) kg/m², FEV1 60% (SD 24) and FVC 81% (SD 21). In univariate analyses, IGT+DM was associated with FEV1 (β = -10.36 p = 0.007) and with FVC (β = -9.69, p = 0.004). Controlling for age, sex, BMI, serum albumin, inflammation and evidence of pulmonary infection did not change these findings. When control ling for these factors in addition to hemoglobin A1c, IGT + DM remained associated with FEV1 (β = -9.27, p= 0.04) and FVC β = -8.61, p = 0.03). In conclusion, DM and IGT, which are present in half of adults with CF, are associated with poor pulmonary function independent of glycemia. These finding are of potential clinical importance, and require confirmation in prospective studies. [ABSTRACT FROM AUTHOR] |
|
Copyright of Diabetes is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder