التفاصيل البيبلوغرافية
| العنوان: |
Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients. |
| المؤلفون: |
Bryant, Laura, Li, Dong, Sherr, Elliott, Thompson, Michelle L, McWalter, Kirsty, Stumpel, Constance T R M, Stevens, Servi J C, Stegmann, Alexander P A, Tveten, Kristian, Vøllo, Arve, Prescott, Trine, Fagerberg, Christina, Laulund, Lone Walentin, Fregeau, Brieana, Larsen, Martin J, Byler, Melissa, Lebel, Robert Roger, Hurst, Anna C, Dean, Joy, Schrier Vergano, Samantha A, Norman, Jennifer, Mercimek-Andrews, Saadet, Neira, Juanita, Van Allen, Margot I, Wierenga, Klaas J, Longo, Nicola, Sellars, Elizabeth, Louie, Raymond J, Cathey, Sara S, Brokamp, Elly, Heron, Delphine, Snyder, Molly, Vanderver, Adeline, Simon, Celeste, de la Cruz, Xavier, Wadley, Alexandrea, Padilla, Natália, Crump, J Gage, Chung, Wendy, Garcia, Benjamin, Hakonarson, Hakon H, Bhoj, Elizabeth J, Mancini, Grazia M S, Powell-Hamilton, Nina, van de Kamp, Jiddeke, Grebe, Theresa, Dean, John, Ross, Alison, Cox, Samuel G, Crawford, Heather P, Powis, Zoe, Cho, Megan T, Willing, Marcia C, Manwaring, Linda, Schot, Rachel, Nava, Caroline, Afenjar, Alexandra, Lessel, Davor, Wagner, Matias, Marchione, Dylan, Klopstock, Thomas, Winkelmann, Juliane, Catarino, Claudia B, Retterer, Kyle, Schuette, Jane L, Innis, Jeffrey W, Pizzino, Amy, Lüttgen, Sabine, Denecke, Jonas, Strom, Tim M, Joiner, Evan F, Monaghan, Kristin G, Study, DDD, Yuan, Zuo-Fei, Dubbs, Holly, Bend, Renee, Lee, Jennifer A, Lyons, Michael J, Hoefele, Julia, Günthner, Roman, Reutter, Heiko, Wilson, Khadija, Keren, Boris, Radtke, Kelly, Sherbini, Omar, Mrokse, Cameron, Helbig, Katherine L, Odent, Sylvie, Cogne, Benjamin, Mercier, Sandra, Bezieau, Stephane, Besnard, Thomas, Janssen, Kevin, Kury, Sebastien, Redon, Richard, Reinson, Karit, Wojcik, Monica H, Õunap, Katrin, Ilves, Pilvi, Innes, A Micheil, Kernohan, Kristin D, Consortium, Care4Rare Canada, Costain, Gregory, Lee, Pearl, Meyn, M Stephen, Chitayat, David, Zackai, Elaine, Lehman, Anna, Kitson, Hilary, Study, CAUSES, Martin, Martin G, Martinez-Agosto, Julian A, Network, Undiagnosed Diseases, Nelson, Stan F, March, Michael E, Palmer, Christina G S, Papp, Jeanette C, Parker, Neil H, Sinsheimer, Janet S, Vilain, Eric, Wan, Jijun, Yoon, Amanda J, Zheng, Allison, Brimble, Elise, Ferrero, Giovanni Battista, Nair, Divya, Radio, Francesca Clementina, Carli, Diana, Barresi, Sabina, Brusco, Alfredo, Tartaglia, Marco, Thomas, Jennifer Muncy, Umana, Luis, Weiss, Marjan M, Gotway, Garrett, Stuurman, K. E. |
| المصدر: |
Science advances 6(49), eabc9207 (2020). doi:10.1126/sciadv.abc9207 |
| بيانات النشر: |
Assoc. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/500, Animals, Forkhead Transcription Factors: genetics, Germ-Line Mutation, Histones: genetics, Histones: metabolism, Humans, Neurodegenerative Diseases: genetics, Zebrafish: genetics, Zebrafish: metabolism, Zebrafish Proteins: metabolism, Forkhead Transcription Factors, H3-3A protein, human, Histones, Zebrafish Proteins, foxd3 protein, zebrafish |
| جغرافية الموضوع: |
DE |
| الوصف: |
Although somatic mutations in Histone 3.3 (H3.3) are well-studied drivers of oncogenesis, the role of germline mutations remains unreported. We analyze 46 patients bearing de novo germline mutations in histone 3 family 3A (H3F3A) or H3F3B with progressive neurologic dysfunction and congenital anomalies without malignancies. Molecular modeling of all 37 variants demonstrated clear disruptions in interactions with DNA, other histones, and histone chaperone proteins. Patient histone posttranslational modifications (PTMs) analysis revealed notably aberrant local PTM patterns distinct from the somatic lysine mutations that cause global PTM dysregulation. RNA sequencing on patient cells demonstrated up-regulated gene expression related to mitosis and cell division, and cellular assays confirmed an increased proliferative capacity. A zebrafish model showed craniofacial anomalies and a defect in Foxd3-derived glia. These data suggest that the mechanism of germline mutations are distinct from cancer-associated somatic histone mutations but may converge on control of cell proliferation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/issn/2375-2548; info:eu-repo/semantics/altIdentifier/pmid/pmid:33268356; https://pub.dzne.de/record/164290Test; https://pub.dzne.de/search?p=id:%22DZNE-2022-00944%22Test |
| الإتاحة: |
https://doi.org/10.1126/sciadv.abc9207Test
https://pub.dzne.de/record/164290Test
https://pub.dzne.de/search?p=id:%22DZNE-2022-00944%22Test |
| حقوق: |
info:eu-repo/semantics/closedAccess |
| رقم الانضمام: |
edsbas.D8A404A2 |
| قاعدة البيانات: |
BASE |
