دورية أكاديمية
Detrimental Effects of ApoE ε4 on Blood-Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer's Disease.
| العنوان: | Detrimental Effects of ApoE ε4 on Blood-Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer's Disease. |
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| المؤلفون: | Kirchner, Kevin, Garvert, Linda, Kühn, Luise, Bonk, Sarah, Grabe, Hans Jörgen, Van der Auwera, Sandra |
| المصدر: | Cells 12(21), 2512 (2023). doi:10.3390/cells12212512 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/570, Humans, Aged, Alzheimer Disease: metabolism, Apolipoprotein E4: genetics, Apolipoprotein E4: metabolism, Blood-Brain Barrier: pathology, Neurodegenerative Diseases, Apolipoproteins E: genetics, blood–brain barrier, amyloid beta, apolipoprotein E, cyclophilin A, low-density lipoprotein receptor-related protein1, matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 3, Apolipoprotein E4, Apolipoproteins E |
| جغرافية الموضوع: | DE |
| الوصف: | Alzheimer's disease (AD) is a progressive neurodegenerative disease representing the most common type of dementia in older adults. The major risk factors include increased age, genetic predisposition and socioeconomic factors. Among the genetic factors, the apolipoprotein E (ApoE) ε4 allele poses the greatest risk. Growing evidence suggests that cerebrovascular dysfunctions, including blood-brain barrier (BBB) leakage, are also linked to AD pathology. Within the scope of this paper, we, therefore, look upon the relationship between ApoE, BBB integrity and AD. In doing so, both brain-derived and peripheral ApoE will be considered. Despite the considerable evidence for the involvement of brain-derived ApoE ε4 in AD, information about the effect of peripheral ApoE ε4 on the central nervous system is scarce. However, a recent study demonstrated that peripheral ApoE ε4 might be sufficient to impair brain functions and aggravate amyloid-beta pathogenesis independent from brain-based ApoE ε4 expression. Building upon recent literature, we provide an insight into the latest research that has enhanced the understanding of how ApoE ε4, secreted either in the brain or the periphery, influences BBB integrity and consequently affects AD pathogenesis. Subsequently, we propose a pathway model based on current literature and discuss future research perspectives. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/2073-4409; info:eu-repo/semantics/altIdentifier/pmid/pmid:37947590; https://pub.dzne.de/record/265941Test; https://pub.dzne.de/search?p=id:%22DZNE-2023-01064%22Test |
| الإتاحة: | https://doi.org/10.3390/cells12212512Test https://pub.dzne.de/record/265941Test https://pub.dzne.de/search?p=id:%22DZNE-2023-01064%22Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2870B053 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |