دورية أكاديمية
Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice.
| العنوان: | Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. |
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| المؤلفون: | Machado, Venissa, Gilsbach, Ralf, Das, Richa, Schober, Andreas, Bogatyreva, Lioudmila, Hauschke, Dieter, Krieglstein, Kerstin, Unsicker, Klaus, Spittau, Björn |
| المصدر: | Cell & tissue research 365(2), 209-223 (2016). doi:10.1007/s00441-016-2406-x |
| بيانات النشر: | Springer |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: administration & dosage, Animals, Biomarkers: metabolism, Cell Proliferation, Cytokines: metabolism, Dopaminergic Neurons: metabolism, Growth Differentiation Factor 15: deficiency, Growth Differentiation Factor 15: metabolism, Inflammation Mediators: metabolism, Mice, Neostriatum: metabolism, Neostriatum: pathology, Neuroglia: metabolism, RNA, Messenger: genetics, Messenger: metabolism, Substantia Nigra: metabolism, Substantia Nigra: pathology, Biomarkers, Cytokines, Gdf15 protein, mouse, Growth Differentiation Factor 15, Inflammation Mediators, Messenger, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
| جغرافية الموضوع: | DE |
| الوصف: | Growth/differentiation factor-15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons both in vitro and in vivo. Gdf-15 has also been shown to be involved in inflammatory processes. The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing Gdf-15 (+/+) and Gdf-15 (-/-) mice. At 4 days and 14 days post-MPTP administration, both Gdf-15 (+/+) and Gdf-15 (-/-) mice showed a similar decline in DAergic neuron numbers and in striatal dopamine (DA) levels. This was followed by a comparable restorative phase at 90 days and 120 days, indicating that the absence of Gdf-15 does not affect the susceptibility or the recovery capacity of the nigrostriatal system after MPTP administration. The MPTP-induced microglial and astrocytic response was not significantly altered between the two genotypes. However, pro-inflammatory and anti-inflammatory cytokine profiling revealed the differential expression of markers in Gdf-15 (+/+) and Gdf-15 (-/-) mice after MPTP administration. Thus, the MPTP mouse model fails to uncover a major role of endogenous Gdf-15 in the protection of MPTP-lesioned nigrostriatal DAergic neurons, in contrast to its capacity to protect the 6-hydroxydopamine-intoxicated nigrostriatal system. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/0044-3794; info:eu-repo/semantics/altIdentifier/issn/0373-031X; info:eu-repo/semantics/altIdentifier/issn/0302-766X; info:eu-repo/semantics/altIdentifier/pmid/pmid:27115420; info:eu-repo/semantics/altIdentifier/issn/1432-0878; info:eu-repo/semantics/altIdentifier/issn/0340-0387; info:eu-repo/semantics/altIdentifier/issn/2192-5917; info:eu-repo/semantics/altIdentifier/issn/0340-0336; https://pub.dzne.de/record/138664Test; https://pub.dzne.de/search?p=id:%22DZNE-2020-04986%22Test |
| الإتاحة: | https://doi.org/10.1007/s00441-016-2406-xTest https://pub.dzne.de/record/138664Test https://pub.dzne.de/search?p=id:%22DZNE-2020-04986%22Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.DD6E4460 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |