المؤلفون: Smatlik, Nikola, Drexler, Stefan Karl, Burian, Marc, Röcken, Martin, Yazdi, Amir Sadegh

المصدر: Oxidative medicine and cellular longevity 2021, 7914829 (2021). doi:10.1155/2021/7914829 special issue: "Role of ROS-Induced NLRP3 Inflammasome Activation in Chronic Diseases and Conditions / Edited by: Tao Zheng, Lead Editor; Fang Bian, Guest Editor; Juyi Li, Guest Editor; Francesca Danesi, Guest Editor"

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/issn/1942-0994; info:eu-repo/semantics/altIdentifier/pmid/pmid:34777694; info:eu-repo/semantics/altIdentifier/issn/1942-0900; info:eu-repo/semantics/altIdentifier/wos/WOS:000749846300006; https://publications.rwth-aachenTest.de/record/851268; https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-248356%22

الإتاحة: https://doi.org/10.1155/2021/7914829Test
https://doi.org/10.18154/RWTH-CONV-248356Test
https://publications.rwth-aachenTest.de/record/851268
https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-248356%22

المؤلفون: Smatlik, Nikola, Mortada, Nourhan, Röcken, Martin, Yazdi, Amir S., Zierhut, Manfred

المصدر: Ocular immunology and inflammation 1-9 (2021). doi:10.1080/09273948.2021.1873396

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:33793375; info:eu-repo/semantics/altIdentifier/issn/1744-5078; info:eu-repo/semantics/altIdentifier/wos/WOS:000635832000001; info:eu-repo/semantics/altIdentifier/issn/0927-3948; https://publications.rwth-aachenTest.de/record/851260; https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-248348%22

الإتاحة: https://doi.org/10.1080/09273948.2021.1873396Test
https://publications.rwth-aachenTest.de/record/851260
https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-248348%22

المؤلفون: De Nardo, Dominic, Labzin, Larisa I, Vogelhuber, Johanna, Kraut, Michael, Ulas, Thomas, Kerksiek, Anja, Krebs, Wolfgang, Bode, Niklas, Grebe, Alena, Fitzgerald, Michael L, Hernandez, Nicholas J, Williams, Bryan R G, Kono, Hajime, Knolle, Percy, Kneilling, Manfred, Röcken, Martin, Lütjohann, Dieter, Wright, Samuel D, Schultze, Joachim L, Latz, Eicke, Seki, Reiko, Schmidt, Susanne V, Beyer, Marc, Xu, Dakang, Zimmer, Sebastian, Lahrmann, Catharina, Schildberg, Frank A

المصدر: Nature immunology 15(2), 152-160 (2013). doi:10.1038/ni.2784

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Activating Transcription Factor 3: genetics, Activating Transcription Factor 3: metabolism, Animals, Anti-Inflammatory Agents, Non-Steroidal: pharmacology, Non-Steroidal: therapeutic use, Atherosclerosis: therapy, Cells, Cultured, Cholesterol: metabolism, Chromatin Immunoprecipitation, Cytokines: metabolism, Female, Gene Expression Profiling, High-Throughput Nucleotide Sequencing, Humans, Inflammation: therapy, Lipoproteins, HDL: pharmacology, HDL: therapeutic use, Macrophage Activation: drug effects, Macrophages: drug effects, Macrophages: immunology, Mice, Inbred C3H, Inbred C57BL, Systems Biology, Toll-Like Receptor 4: genetics, Toll-Like Receptor 4: immunology

جغرافية الموضوع: DE

الوصف: High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory diseases. The molecular mechanisms of how HDL can modulate inflammation, particularly in immune cells such as macrophages, remain poorly understood. Here we identify the transcriptional regulator ATF3, as an HDL-inducible target gene in macrophages that downregulates the expression of Toll-like receptor (TLR)-induced proinflammatory cytokines. The protective effects of HDL against TLR-induced inflammation were fully dependent on ATF3 in vitro and in vivo. Our findings may explain the broad anti-inflammatory and metabolic actions of HDL and provide the basis for predicting the success of new HDL-based therapies.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:24317040; info:eu-repo/semantics/altIdentifier/issn/1529-2916; info:eu-repo/semantics/altIdentifier/issn/1529-2908; https://pub.dzneTest.de/record/137220; https://pub.dzneTest.de/search?p=id:%22DZNE-2020-03542%22

الإتاحة: https://doi.org/10.1038/ni.2784Test
https://pub.dzneTest.de/record/137220
https://pub.dzneTest.de/search?p=id:%22DZNE-2020-03542%22

المؤلفون: van Beek, Nina, Knuth-Rehr, Diana, Fischer, Matthias, Glaenz, Thomas, Gläser, Regine, Goebeler, Matthias, Gollnick, Harald, Götze, Steven, Gross, Gerd, Hadaschik, Eva, Herbst, Rudolf, Hermes, Barbara, Altmeyer, Peter, Homey, Bernhard, Hunzelmann, Nico, Jünger, Michael, Kapp, Alexander, Kern, Johannes S., Körber, Andreas, Luger, Thomas, Mechtel, Dirk, Megahed, Mosaad, Moll, Ingrid, Assaf, Chalid, Peters, Klaus-Peter, Pfeiffer, Christiane, Ring, Johannes, Röcken, Martin, Sárdy, Miklos, Seitz, Cornelia S., Stadler, Rudolf, Steinbrink, Kerstin, Sticherling, Michael, Szeimies, Rolf-Markus, Babilas, Philipp, Tronnier, Michael, Ulrich, Jens, Vogt, Thomas, Wagner, Nicola, Welzel, Julia, Wenzel, Jörg, Wozel, Gottfried, Zouboulis, Christos C., Zillikens, Detlef, Schmidt, Enno, Bayerl, Christiane, Benoit, Sandrine, Dippel, Edgar, Effendy, Isaak, Eming, Rüdiger

المصدر: Journal der Deutschen Dermatologischen Gesellschaft : JDDG 10(7), 492-499 (2012). doi:10.1111/j.1610-0387.2011.07840.x

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/issn/1610-0387; info:eu-repo/semantics/altIdentifier/issn/1610-0379; info:eu-repo/semantics/altIdentifier/wos/WOS:000305605300005; info:eu-repo/semantics/altIdentifier/pmid/pmid:22304433; https://publications.rwth-aachenTest.de/record/198276; https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-072603%22

الإتاحة: https://doi.org/10.1111/j.1610-0387.2011.07840.xTest
https://publications.rwth-aachenTest.de/record/198276
https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-072603%22

المؤلفون: Ulmer, Anja, Beutel, Julia, Grisanti, Salvatore, Süsskind, Daniela, Hilgers, Ralf-Dieter, Ziemssen, Focke, Lüke, Matthias, Röcken, Martin, Rohrbach, Martin, Fierlbeck, Gerhard, Bartz-Schmidt, Karl Ulrich

المصدر: Clinical cancer research 14(14), 4469-4474 (2008). doi:10.1158/1078-0432.CCR-08-0012

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:18628461; info:eu-repo/semantics/altIdentifier/wos/WOS:000257785500015; info:eu-repo/semantics/altIdentifier/issn/1078-0432; info:eu-repo/semantics/altIdentifier/issn/1557-3265; https://publications.rwth-aachenTest.de/record/164458; https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-042365%22

الإتاحة: https://doi.org/10.1158/1078-0432.CCR-08-0012Test
https://publications.rwth-aachenTest.de/record/164458
https://publications.rwth-aachenTest.de/search?p=id:%22RWTH-CONV-042365%22