التفاصيل البيبلوغرافية
| العنوان: |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia |
| المؤلفون: |
Trubetskoy, Vassily, Pardiñas, Antonio F., Lam, Max, Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopal, Srihari, Gratten, Jacob, Green, Michael F., Watanabe, Kyoko, Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Frei, Oleksandr, Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Ge, Tian, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Harwood, Janet C., Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Kučinskiene, Zita Ausrele, Kusumawardhani, Agung, Kuzelova-Ptackova, Hana, Landi, Stefano, Lazzeroni, Laura C., Koopmans, Frank, Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Magnusson, Sigurdur, Lönnqvist, Jouko, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Macek, Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Richards, Alexander L., Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Sidorenko, Julia, Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mitjans, Marina, Wu, Yang, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Qi, Ting, Zeng, Jian, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Nuechterlein, Keith H., O’Brien, Niamh Louise, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Grove, Jakob, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietiläinen, Olli, Pimm, Jonathan, Porteous, David, Kim, Minsoo, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Li, Zhiqiang, Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Voloudakis, Georgios, Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Siever, Larry J., Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Zhang, Wen, Söderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes A., Stögmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Strengman, Eric, Stroup, T. Scott, Adams, Mark, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, Takahashi, Atsushi, Terao, Chikashi, Thibaut, Florence, Agartz, Ingrid, Toncheva, Draga, Tooney, Paul A., Torretta, Silvia, Tosato, Sarah, Tura, Gian Battista, Turetsky, Bruce I., Üçok, Alp, Vaaler, Arne, van Amelsvoort, Therese, van Winkel, Ruud, Atkinson, Elizabeth G., Veijola, Juha, Waddington, John, Walter, Henrik, Waterreus, Anna, Webb, Bradley T., Weiser, Mark, Williams, Nigel M., Witt, Stephanie H., Wormley, Brandon K., Wu, Jing Qin, Agerbo, Esben, Xu, Zhida, Yolken, Robert, Zai, Clement C., Zhou, Wei, Zhu, Feng, Zimprich, Fritz, Atbaşoğlu, Eşref Cem, Ayub, Muhammad, Benner, Christian, Bertolino, Alessandro, Panagiotaropoulou, Georgia, Al Eissa, Mariam, Black, Donald W., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Byerley, William F., Chen, Wei J., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Freedman, Robert, Albus, Margot, Galletly, Cherrie, Gandal, Michael J., Gennarelli, Massimo, Hougaard, David M., Hwu, Hai-Gwo, Jablensky, Assen V., McCarroll, Steven A., Moran, Jennifer L., Mors, Ole, Mortensen, Preben B., Alexander, Madeline, Müller-Myhsok, Bertram, Neil, Amanda L., Nordentoft, Merete, Pato, Michele T., Petryshen, Tracey L., Pirinen, Matti, Pulver, Ann E., Schulze, Thomas G., Silverman, Jeremy M., Smoller, Jordan W., Alizadeh, Behrooz Z., Stahl, Eli A., Tsuang, Debby W., Vilella, Elisabet, Wang, Shi-Heng, Xu, Shuhua, Dai, Nan, Wenwen, Qin, Wildenauer, D. B., Agiananda, Feranindhya, Amir, Nurmiati, Alptekin, Köksal, Antoni, Ronald, Arsianti, Tiana, Asmarahadi, Asmarahadi, Diatri, H., Djatmiko, Prianto, Irmansyah, Irmansyah, Khalimah, Siti, Kusumadewi, Irmia, Kusumaningrum, Profitasari, Lukman, Petrin R., Als, Thomas D., Nasrun, Martina W., Safyuni, N. S., Prasetyawan, Prasetyawan, Semen, G., Siste, Kristiana, Tobing, Heriani, Widiasih, Natalia, Wiguna, Tjhin, Wulandari, D., Evalina, None, Amin, Farooq, Hananto, A. J., Ismoyo, Joni H., Marini, T. M., Henuhili, Supiyani, Reza, Muhammad, Yusnadewi, Suzy, Abyzov, Alexej, Akbarian, Schahram, Ashley-Koch, Allison, van Bakel, Harm, Arolt, Volker, Breen, Michael, Brown, Miguel, Bryois, Julien, Carlyle, Becky, Charney, Alex, Coetzee, Gerard, Crawford, Gregory, Dracheva, Stella, Emani, Prashant, Farnham, Peggy, Arrojo, Manuel, Fromer, Menachem, Galeev, Timur, Gandal, Mike, Gerstein, Mark, Giase, Gina, Girdhar, Kiran, Goes, Fernando, Grennan, Kay, Gu, Mengting, Guerra, Brittney, Athanasiu, Lavinia, Gursoy, Gamze, Hoffman, Gabriel, Hyde, Thomas, Jaffe, Andrew, Jiang, Shan, Jiang, Yan, Kefi, Amira, Kim, Yunjung, Kitchen, Robert, Knowles, James A., Awasthi, Swapnil, Azevedo, Maria Helena, Lay, Fides, Lee, Donghoon, Li, Mingfeng, Liu, Chunyu, Liu, Shuang, Mattei, Eugenio, Navarro, Fabio, Pan, Xinghua, Peters, Mette A., Pinto, Dalila, Bacanu, Silviu A., Pochareddy, Sirisha, Polioudakis, Damon, Purcaro, Michael, Purcell, Shaun, Pratt, Henry, Reddy, Tim, Rhie, Suhn, Roussos, Panagiotis, Rozowsky, Joel, Sanders, Stephan, Bass, Nicholas J., Sestan, Nenad, Sethi, Anurag, Shi, Xu, Shieh, Annie, Swarup, Vivek, Szekely, Anna, Wang, Daifeng, Warrell, Jonathan, Weissman, Sherman, Weng, Zhiping, Begemann, Martin, White, Kevin, Wiseman, Jennifer, Witt, Heather, Won, Hyejung, Wood, Shannon, Wu, Feinan, Xu, Xuming, Yao, Lijing, Zandi, Peter, Arranz, Maria J., Belliveau, Richard A., Bakker, Steven, Bender, Stephan, Bramon, Elvira, Collier, David A., Crepo-Facorro, Benedicto, Hall, Jeremy, Kahn, René, Lawrie, Stephen, Lewis, Cathryn, Bene, Judit, Lin, Kuang, Linszen, Don H., Mata, Ignacio, McIntosh, Andrew, Murray, Robin M., Ophoff, Roel A., van Os, Jim, Rujescu, Dan, Walshe, Muriel, Benyamin, Beben, Weisbrod, Matthias, Achsel, Tilmann, Andres-Alonso, Maria, Bagni, Claudia, Bayés, Àlex, Biederer, Thomas, Brose, Nils, Brown, Tyler C., Chua, John Jia En, Coba, Marcelo P., Bergen, Sarah E., Cornelisse, L. Niels, de Jong, Arthur P. H., de Juan-Sanz, Jaime, Dieterich, Daniela C., Feng, Guoping, Goldschmidt, Hana L., Gundelfinger, Eckart D., Hoogenraad, Casper, Huganir, Richard L., Hyman, Steven E., Blasi, Giuseppe, Imig, Cordelia, Jahn, Reinhard, Jung, Hwajin, Kaeser, Pascal S., Kim, Eunjoon, Kreutz, Michael R., Lipstein, Noa, MacGillavry, Harold D., Malenka, Robert, Bobes, Julio, McPherson, Peter S., O’Connor, Vincent, Pielot, Rainer, Ryan, Timothy A., Sahasrabudhe, Dnyanada, Sala, Carlo, Sheng, Morgan, Smalla, Karl-Heinz, Smit, August B., Südhof, Thomas C., Bigdeli, Tim B., Bonassi, Stefano, Thomas, Paul D., Toonen, Ruud F., van Weering, Jan R. T., Verhage, Matthijs, Verpelli, Chiara, Adolfsson, Rolf, Arango, Celso, Baune, Bernhard T., Belangero, Sintia Iole, Børglum, Anders D., Braun, Alice, Braff, David, Buxbaum, Joseph D., Campion, Dominique, Cervilla, Jorge A., Cichon, Sven, Corvin, Aiden, Curtis, David, Forti, Marta Di, Bressan, Rodrigo Affonseca, Domenici, Enrico, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Fanous, Ayman H., Gareeva, Anna, Gawlik, Micha, Gejman, Pablo V., Gill, Michael, Glatt, Stephen J., Bromet, Evelyn J., Golimbet, Vera, Hong, Kyung Sue, Hultman, Christina M., Iwata, Nakao, Jönsson, Erik G., Kahn, René S., Kennedy, James L., Khusnutdinova, Elza, Kirov, George, Bruggeman, Richard, Krebs, Marie-Odile, Laurent-Levinson, Claudine, Lee, Jimmy, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., Malhotra, Dheeraj, Buckley, Peter F., McQuillin, Andrew, Menezes, Paulo R., Morgan, Vera A., Morris, Derek W., Mowry, Bryan J., Nimgaonkar, Vishwajit, Nöthen, Markus M., Buckner, Randy L., Paciga, Sara A., Palotie, Aarno, Pato, Carlos N., Qin, Shengying, Rietschel, Marcella, Riley, Brien P., Rivera, Margarita, Saka, Meram C., Sanders, Alan R., Bybjerg-Grauholm, Jonas, Schwab, Sibylle G., Serretti, Alessandro, Sham, Pak C., Shi, Yongyong, St Clair, David, Stefánsson, Hreinn, Stefansson, Kari, Tsuang, Ming T., Vawter, Marquis P., Cahn, Wiepke, Weinberger, Daniel R., Werge, Thomas, Wildenauer, Dieter B., Yu, Xin, Yue, Weihua, Holmans, Peter A., Pocklington, Andrew J., Roussos, Panos, Vassos, Evangelos, Cairns, Murray J., Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Kendler, Kenneth S., Owen, Michael J., Wray, Naomi R., Daly, Mark J., Huang, Hailiang, Neale, Benjamin M., Calkins, Monica E., Sullivan, Patrick F., Ripke, Stephan, Walters, James T. R., O’Donovan, Michael C., de Haan, Lieuwe, Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Chen, Chia-Yen, Cohen, David, Consoli, Angèle, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, DeLisi, Lynn E., Dennison, Charlotte A., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fañanás, Lourdes, Hall, Lynsey S., Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S. |
| المصدر: |
Nature 604, 502–508 (2022). doi:10.1038/s41586-022-04434-5 |
| بيانات النشر: |
Nature Publ. Group |
| سنة النشر: |
2022 |
| المجموعة: |
Forschungszentrum Jülich: JuSER (Juelich Shared Electronic Resources) |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/500 |
| جغرافية الموضوع: |
DE |
| الوصف: |
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/issn/1476-4687; info:eu-repo/semantics/altIdentifier/pmid/35396580; info:eu-repo/semantics/altIdentifier/issn/0028-0836; info:eu-repo/semantics/altIdentifier/wos/WOS:000779867500004; info:eu-repo/semantics/altIdentifier/hdl/2128/33199; https://juser.fz-juelich.de/record/907296Test; https://juser.fz-juelich.de/search?p=id:%22FZJ-2022-01947%22Test |
| الإتاحة: |
https://doi.org/10.1038/s41586-022-04434-5Test
https://juser.fz-juelich.de/record/907296Test
https://juser.fz-juelich.de/search?p=id:%22FZJ-2022-01947%22Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.381E6C86 |
| قاعدة البيانات: |
BASE |
