التفاصيل البيبلوغرافية
| العنوان: |
An astrocytic basis of caloric restriction action on the brain plasticity |
| المؤلفون: |
Plata Ayala, Alex Fernell, Popov, Alexander, Denisov, Pavel, Bychkov, Maxim, Brazhe, Alexey, Lyukmanova, Ekaterina, Lazareva, Natalia, Verkhratsky, Alexei, Semyanov, Alexey |
| بيانات النشر: |
BioRxiv preprint |
| سنة النشر: |
2019 |
| المجموعة: |
Colecciones digitales - Biblioteca Virtual del Banco de la República |
| مصطلحات موضوعية: |
Astrocyte, Calcium, Glutamate transporters, Spillover, LTP, Caloric restriction, Ciencias naturales y matemáticas / Ciencias de la vida Biología, Tecnología |
| جغرافية الموضوع: |
Colombia |
| الوصف: |
One month of calorically restricted diet (CR) induced morphological plasticity of astrocytes in the stratum (str.) radiatum of hippocampal CA1 in three-months old mice: the volume fraction of distal perisynaptic astrocytic processes increased whereas the number of gap-junction coupled astrocytes decreased. The uncoupling was not associated with a decrease in the expression of connexin 43. Uncoupling and morphological remodeling affected spontaneous Ca2+ activity in the astrocytic network: Ca2+ events became longer, whereas their spread was reduced. The change in the pattern of astrocytic Ca2+ activity may increase the spatial resolution of the information encoding in the astroglial network. Consistent with expanded synaptic enwrapping by the astroglial processes, the spillover of synaptically released K+ and glutamate was diminished after CR. However, no significant changes in the expression of astrocytic glutamate transporter (GLT-1/EAAT2) were observed, although the level of glutamine synthetase was decreased. Glutamate uptake is known to regulate the synaptic plasticity. Indeed, the magnitude of long-term potentiation (LTP) in the glutamatergic CA3-CA1 synapses was significantly enhanced after CR. Our findings highlight an astroglial basis for improved learning and memory reported in various species subjected to CR. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
PDF |
| اللغة: |
English |
| العلاقة: |
Colfuturo; http://babel.banrepcultural.org/cdm/ref/collection/p17054coll23/id/1692Test |
| الإتاحة: |
http://babel.banrepcultural.org/cdm/ref/collection/p17054coll23/id/1692Test |
| حقوق: |
© Derechos reservados del autor |
| رقم الانضمام: |
edsbas.312A16EB |
| قاعدة البيانات: |
BASE |
