التفاصيل البيبلوغرافية
| العنوان: |
Process validation for production of copper radioisotopes in a TR-19 variable energy cyclotron. |
| المؤلفون: |
Leonte, R. A.1 (AUTHOR), Cocioabă, D.1,2 (AUTHOR) diana.cocioaba@nipne.ro, Chilug, L. E.1,3 (AUTHOR), Băruță (Ilie), S. I.1,4 (AUTHOR) simona.baruta@nipne.ro, Eșanu, T. R.1 (AUTHOR), Burghelea, B.1 (AUTHOR), Chiriacescu, A.1,2 (AUTHOR), Crăciun, L. S.1 (AUTHOR), Niculae, D.1 (AUTHOR), Kok, Kuan-Ying5,6 (AUTHOR), Ng, Yen5,6 (AUTHOR), Zin, Muhammad Rawi Muhamed5,6 (AUTHOR), Mahmood, Zal U'yun Wan5,6 (AUTHOR), Ahmad, Zaiton5,6 (AUTHOR), Idris, Faridah Mohamad5,6 (AUTHOR), Mahmoud, Mahdi Ezwan5,6 (AUTHOR), Sipaun, Susan Maria5,6 (AUTHOR), Talib, Marina5,6 (AUTHOR), Leo, Kwee-Wah5,6 (AUTHOR), Hak, Cik Rohaida Che5,6 (AUTHOR) |
| المصدر: |
AIP Conference Proceedings. 2020, Vol. 2295 Issue 1, p1-7. 7p. |
| مصطلحات موضوعية: |
*CYCLOTRONS, *LINEAR energy transfer, *RADIOISOTOPES, *NUCLEAR reactions, *ELECTRON capture, *POSITRON emission tomography |
| مصطلحات جغرافية: |
ITALY, CANADA |
| مستخلص: |
64Cu is a cyclotron-produced radionuclide suitable for positron emission tomography (PET) and internal radiotherapy. We have been focused on 64Cu radioisotope due to its favorable nuclear characteristics (β+ emission, 18% and β− emission, 39%). Moreover, the electron capture (43%) implies Auger electron emission with high linear energy transfer in the targeted cells. Also, the 12.7 hours half-life allows a good uptake and distribution of the radiopharmaceuticals to obtain qualitative images with high contrast. The production of no-carrier-added 64Cu via the 64Ni(p,n)64Cu nuclear reaction using a variable energy cyclotron (TR-19, ACSI, Canada) was studied in our work involving the implementation of a fully automated solid target irradiation and processing system. In this paper we report the validation of the process for the automated production and purification of 64Cu produced in a variable energy (14-19 MeV) cyclotron, using a commercially available automated solid target system (ALCEO, Comecer S.p.A, Italy), comprising modules for electrodeposition, pneumatic transfer, irradiation unit, dissolving and purification. The obtained 64CuCl2 solution complies with the requirements of a radiopharmaceutical for medical applications. The process is to be translated for production of other copper radioisotopes of medical interest. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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