التفاصيل البيبلوغرافية
| العنوان: |
Feasibility, accuracy and acceptability of self-sampled human papillomavirus testing using careHPV in Cambodia: a cross-sectional study. |
| المؤلفون: |
Sovanara Hang, Rei Haruyama, Kyna Uy, Noriko Fujita, Tadashi Kimura, Kanal Koum, Kei Kawana |
| المصدر: |
Journal of Gynecologic Oncology; Jan2024, Vol. 35 Issue 1, p1-11, 11p |
| مصطلحات موضوعية: |
HUMAN papillomavirus, PAP test, CROSS-sectional method, POLYMERASE chain reaction, CAPITAL cities, PUBLIC hospitals, CERVICAL intraepithelial neoplasia |
| مصطلحات جغرافية: |
CAMBODIA |
| مستخلص: |
Objective: Self-sampled human papillomavirus (HPV) testing is a potential option for cervical cancer screening, but research is scarce in Cambodia. We evaluated the feasibility, accuracy, and acceptability of self-sampled HPV testing using careHPV. Methods: A cross-sectional study including women aged 20-49 years attending 2 national hospitals in the capital city was conducted. Women underwent both self-sampling and clinician-sampling of specimens, and were then asked to complete an acceptability questionnaire. The paired samples were analyzed for high-risk HPV by careHPV and genotyped by polymerase chain reaction (PCR). Results: A total of 375 women were eligible for inclusion. Based on PCR, 78.9% were negative for HPV in both self and clinician-samples, 9.9% had a complete HPV type match, and 6.1% had all HPV types in clinician-samples also detected in self-samples. In 5.1%, one or more HPV types identified in the clinician-samples were missed in self-samples. When using careHPV, the overall agreement between the 2 sampling methods was 95.7% (95% confidence interval [CI]=95.8-95.6) with good concordance (κ=0.66, 95% CI=0.56-0.76). Nearly 90% of the women preferred clinician-sampling over self-sampling, citing greater comfort, ease, and speed. Conclusion: Self-sampled HPV testing using careHPV could be an option for cervical cancer screening in Cambodia; however, it requires periodic quality control of handling procedures. In addition, women's health education regarding the accuracy of self-sampled HPV testing and the importance of follow-up in cases of positive results is needed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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