التفاصيل البيبلوغرافية
| العنوان: |
Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study. |
| المؤلفون: |
Roh, Michelle E1 (AUTHOR) michelle.roh@ucsf.edu, Zongo, Issaka2 (AUTHOR), Haro, Alassane2 (AUTHOR), Huang, Liusheng3 (AUTHOR), Somé, Anyirékun Fabrice2 (AUTHOR), Yerbanga, Rakiswendé Serge2 (AUTHOR), Conrad, Melissa D4 (AUTHOR), Wallender, Erika3 (AUTHOR), Legac, Jennifer4 (AUTHOR), Aweeka, Francesca3 (AUTHOR), Ouédraogo, Jean-Bosco2,5 (AUTHOR), Rosenthal, Philip J4 (AUTHOR) |
| المصدر: |
Journal of Infectious Diseases. 10/1/2023, Vol. 228 Issue 7, p926-935. 10p. |
| مصطلحات موضوعية: |
*DRUG resistance, *CHEMOPREVENTION, *MALARIA, *CASE-control method, *HEALTH facilities, *SEASONAL variations of diseases |
| مصطلحات جغرافية: |
BURKINA Faso |
| مستخلص: |
Background Despite scale-up of seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ) in children 3–59 months of age in Burkina Faso, malaria incidence remains high, raising concerns regarding SMC effectiveness and selection of drug resistance. Using a case-control design, we determined associations between SMC drug levels, drug resistance markers, and presentation with malaria. Methods We enrolled 310 children presenting at health facilities in Bobo-Dioulasso. Cases were SMC-eligible children 6–59 months of age diagnosed with malaria. Two controls were enrolled per case: SMC-eligible children without malaria; and older (5–10 years old), SMC-ineligible children with malaria. We measured SP-AQ drug levels among SMC-eligible children and SP-AQ resistance markers among parasitemic children. Conditional logistic regression was used to compute odds ratios (ORs) comparing drug levels between cases and controls. Results Compared to SMC-eligible controls, children with malaria were less likely to have any detectable SP or AQ (OR, 0.33 [95% confidence interval,.16–.67]; P =.002) and have lower drug levels (P <.05). Prevalences of mutations mediating high-level SP resistance were rare (0%–1%) and similar between cases and SMC-ineligible controls (P >.05). Conclusions Incident malaria among SMC-eligible children was likely due to suboptimal levels of SP-AQ, resulting from missed cycles rather than increased antimalarial resistance to SP-AQ. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
