التفاصيل البيبلوغرافية
| العنوان: |
64Cu-PSMA-BCH: a new radiotracer for delayed PET imaging of prostate cancer. |
| المؤلفون: |
Liu, Teli, Liu, Chen, Zhang, Zhongyi, Zhang, Ning, Guo, Xiaoyi, Xia, Lei, Jiang, Jinquan, Xie, Qing, Yan, Kun, Rowe, Steven P., Zhu, Hua, Yang, Zhi |
| المصدر: |
European Journal of Nuclear Medicine & Molecular Imaging; Dec2021, Vol. 48 Issue 13, p4508-4516, 9p, 1 Color Photograph, 3 Charts, 3 Graphs |
| مصطلحات موضوعية: |
RADIOACTIVE tracers, POSITRON emission tomography, ENDORECTAL ultrasonography, AUTORADIOGRAPHY, COMPUTED tomography, PROSTATE cancer, RADIATION dosimetry, PROSTATE cancer patients |
| مصطلحات جغرافية: |
BEIJING (China) |
| مستخلص: |
Purpose: Develop a 64Cu labeled radiopharmaceutical targeting prostate specific membrane antigen (PSMA) and investigate its application for prostate cancer imaging. Methods: 64Cu-PSMA-BCH was prepared and investigated for stability, PSMA specificity, and micro-PET imaging. With the approval of Ethics Committee of Beijing Cancer Hospital (No. 2017KT97), PET/CT imaging in 4 patients with suspected prostate cancer was performed and the radiation dosimetry was estimated. Then, PSMA PET-ultrasound image-guided biopsies were performed on 3 patients and the fine needle aspirates were further performed for autoradiography and immunohistochemistry analysis. Results: 64Cu-PSMA-BCH was prepared with high radiochemical yield and stability. In vivo study showed higher uptake in PSMA (+) 22Rv1 cells than PSMA (−) PC-3 cells (5.59 ± 0.36 and 1.97 ± 0.22 IA%/106 cells at 1 h). It accumulated in 22Rv1 tumor with increasing radioactivity uptake and T/N ratios from 1 to 24 h post-injection. In patients with suspected prostate cancer, SUVmax and T/N ratios increased within 24 h post-injection. Compared with image at 1 h post-injection, more tumor lesions were detected at 6 h and 24 h post-injection. The human organ radiation dosimetry showed gallbladder wall was most critical, liver and kidneys were followed, and the whole-body effective dose was 0.0292 mSv/MBq. Two fine needle aspirates obtained by PET-ultrasound-guided targeted biopsy showed high radioactive signal by autoradiography, with 100% PSMA expression in cytoplasm and 30% expression in nucleus. Conclusion: 64Cu-PSMA-BCH was PSMA specific and showed high stability in vivo with lower uptake in liver than 64Cu-PSMA-617. Biodistribution in mice and PCa patients showed similar profile compared with other PSMA ligands and it was safe with moderate effective dosimetry. The increased tumor uptake and T/N ratios by delayed imaging may facilitate the detection of small lesions and guiding targeted biopsies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
