التفاصيل البيبلوغرافية
| العنوان: |
Deciphering Streptococcal Biofilms |
| المؤلفون: |
Puja Yadav, Shalini Verma, Richard Bauer, Monika Kumari, Meenakshi Dua, Atul Kumar Johri, Vikas Yadav, Barbara Spellerberg |
| المصدر: |
Microorganisms; Volume 8; Issue 11; Pages: 1835 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
streptococci, opportunistic pathogen, planktonic, biofilm, antibiotic therapy, quorum sensing (QS) |
| جغرافية الموضوع: |
agris |
| الوصف: |
Streptococci are a diverse group of bacteria, which are mostly commensals but also cause a considerable proportion of life-threatening infections. They colonize many different host niches such as the oral cavity, the respiratory, gastrointestinal, and urogenital tract. While these host compartments impose different environmental conditions, many streptococci form biofilms on mucosal membranes facilitating their prolonged survival. In response to environmental conditions or stimuli, bacteria experience profound physiologic and metabolic changes during biofilm formation. While investigating bacterial cells under planktonic and biofilm conditions, various genes have been identified that are important for the initial step of biofilm formation. Expression patterns of these genes during the transition from planktonic to biofilm growth suggest a highly regulated and complex process. Biofilms as a bacterial survival strategy allow evasion of host immunity and protection against antibiotic therapy. However, the exact mechanisms by which biofilm-associated bacteria cause disease are poorly understood. Therefore, advanced molecular techniques are employed to identify gene(s) or protein(s) as targets for the development of antibiofilm therapeutic approaches. We review our current understanding of biofilm formation in different streptococci and how biofilm production may alter virulence-associated characteristics of these species. In addition, we have summarized the role of surface proteins especially pili proteins in biofilm formation. This review will provide an overview of strategies which may be exploited for developing novel approaches against biofilm-related streptococcal infections. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Biofilm; https://dx.doi.org/10.3390/microorganisms8111835Test |
| DOI: |
10.3390/microorganisms8111835 |
| الإتاحة: |
https://doi.org/10.3390/microorganisms8111835Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F9CC4247 |
| قاعدة البيانات: |
BASE |
