التفاصيل البيبلوغرافية
| العنوان: |
Musculoskeletal Pain, a Possible Indicator of Central Sensitization, Is Positively Associated With Lower Urinary Tract Symptom Progression in Community-Dwelling Older Men. |
| المؤلفون: |
Senders, Angela, Bauer, Scott R, Chen, Yiyi, Oken, Barry, Fink, Howard A, Lane, Nancy E, Sajadi, Kamran P, Marshall, Lynn M |
| المساهمون: |
Lipsitz, Lewis A |
| المصدر: |
The Journals of Gerontology Series A, vol 78, iss 6 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2023 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Allied Health and Rehabilitation Science, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Pediatric Research Initiative, Neurosciences, Urologic Diseases, Aging, Chronic Pain, Pain Research, Male, Humans, Aged, Independent Living, Prospective Studies, Musculoskeletal Pain, Central Nervous System Sensitization, Lower Urinary Tract Symptoms, Epidemiology, Gerontology |
| جغرافية الموضوع: |
997 - 1004 |
| الوصف: |
BackgroundMusculoskeletal pain, a possible marker of central sensitization, is associated with higher prevalence of lower urinary tract symptoms (LUTS) among older men. We investigated whether musculoskeletal pain is associated with LUTS progression.MethodsParticipants were 5569 men age ≥65years enrolled in the prospective, multicenter Osteoporotic Fractures in Men (MrOS) Study. Self-reported musculoskeletal pain within 12months before baseline was categorized as any pain and multilocation pain. Pain interference within 4 weeks of baseline was assessed with the SF-12 questionnaire. LUTS were assessed repeatedly with the American Urological Association Symptom Index (AUA-SI). Men with severe LUTS at baseline were excluded. LUTS progression was defined as the first occurrence of a ≥4-point AUA-SI increase during a 2-year follow-up interval. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were estimated using multivariable pooled logistic regression.ResultsLUTS progression was 37% higher among men with any musculoskeletal pain compared with men without pain (IRR 1.37, 95% CI: 1.21, 1.54). Positive associations were also observed between LUTS progression and pain at 1 (IRR 1.31, 95% CI: 1.13, 1.48) and ≥2 locations (IRR 1.42, 95% CI: 1.24, 1.60). Compared with men without pain interference, men with quite a bit/extreme pain interference were most likely to experience LUTS progression (minimal interference IRR 1.15, 95% CI: 1.03, 1.26; moderate interference IRR 1.28, 95% CI: 1.11, 1.45; quite a bit/extreme interference IRR 1.47, 95% CI: 1.22, 1.71).ConclusionsAmong men initially without severe LUTS, musculoskeletal pain is associated with an increased risk of LUTS progression. Studies using validated measures of central sensitization and LUTS progression among men are warranted. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt1vj2f6vd; https://escholarship.org/uc/item/1vj2f6vdTest |
| الإتاحة: |
https://escholarship.org/uc/item/1vj2f6vdTest |
| حقوق: |
CC-BY |
| رقم الانضمام: |
edsbas.9BB65D07 |
| قاعدة البيانات: |
BASE |
