التفاصيل البيبلوغرافية
| العنوان: |
Heavy Menstrual Bleeding Treatment With a Levonorgestrel 52-mg Intrauterine Device |
| المؤلفون: |
Creinin, Mitchell D, Barnhart, Kurt T, Gawron, Lori M, Eisenberg, David, Mabey, R Garn, Jensen, Jeffrey T |
| المصدر: |
Obstetrics and Gynecology, vol 141, iss 5 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2023 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Trials and Supportive Activities, Clinical Research, Obesity, Good Health and Well Being, Female, Humans, Pregnancy, Intrauterine Devices, Medicated, Levonorgestrel, Menorrhagia, Prospective Studies, Treatment Outcome, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine |
| جغرافية الموضوع: |
971 - 978 |
| الوصف: |
ObjectiveTo evaluate heavy menstrual bleeding treatment outcomes with levonorgestrel 52-mg intrauterine device (IUD) use in participants without body mass index (BMI) or parity restrictions.MethodsInvestigators included participants aged 18-50 years with no pelvic or systemic pathology causing heavy menstrual bleeding at 29 U.S. centers in a prospective trial. Participants had up to three screening cycles with menstrual product collection for alkaline hematin blood-loss measurements. Investigators enrolled those with two menses with blood loss of 80 mL or more (values averaged for baseline blood loss), placed the IUD, and followed participants for up to six 28-day cycles. Participants collected any menstrual products used during cycles 3 and 6 for blood-loss measurement. We evaluated outcomes in participants with at least one follow-up assessment for the primary outcome of median absolute blood-loss change and, secondarily, treatment success , defined as the proportion with a final measured blood loss less than 80 mL and at least 50% reduction from baseline. We evaluated exploratory outcomes of differences in blood-loss changes by BMI and parity using Wilcoxon rank sum test.ResultsOf 105 enrolled participants, 47 (44.8%) had obesity (BMI 30.0 or higher) and 29 (27.6%) were nulliparous. Baseline mean blood loss ranged from 73 to 520 mL (median 143 mL, interquartile range 112-196 mL). Eighty-nine (84.8%) had at least one evaluable follow-up evaluation. Participants had median (interquartile range) absolute blood-loss decreases at cycles 3 (n=86) and 6 (n=81) of 93.3% (86.1-97.7%) and 97.6% (90.4-100%), respectively. At cycle 6, participants without obesity (n=43) and with obesity (n=38) had similar median [interquartile range] decreases (97.6% [91.8-100%] and 97.5% [90.3-100%], respectively; P =.89), with comparable findings for nulliparous (n=25) and parous (n=56) participants (97.0% [91.7-99.1%] and 98.1% [89.9-100%], respectively; P =.43). Treatment success occurred in 81.8% (95% CI 74.2-89.4%) of 99 ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt871128fg; https://escholarship.org/uc/item/871128fgTest |
| الإتاحة: |
https://escholarship.org/uc/item/871128fgTest |
| حقوق: |
CC-BY-NC-ND |
| رقم الانضمام: |
edsbas.DA564C11 |
| قاعدة البيانات: |
BASE |
