دورية أكاديمية
Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder.
| العنوان: | Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. |
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| المؤلفون: | Abrams, Alexander J, Hufnagel, Robert B, Rebelo, Adriana, Zanna, Claudia, Patel, Neville, Gonzalez, Michael A, Campeanu, Ion J, Griffin, Laurie B, Groenewald, Saskia, Strickland, Alleene V, Tao, Feifei, Speziani, Fiorella, Abreu, Lisa, Schüle, Rebecca, Caporali, Leonardo, La Morgia, Chiara, Maresca, Alessandra, Liguori, Rocco, Lodi, Raffaele, Ahmed, Zubair M, Sund, Kristen L, Wang, Xinjian, Krueger, Laura A, Peng, Yanyan, Prada, Carlos E, Prows, Cynthia A, Schorry, Elizabeth K, Antonellis, Anthony, Zimmerman, Holly H, Abdul-Rahman, Omar A, Yang, Yaping, Downes, Susan M, Prince, Jeffery, Fontanesi, Flavia, Barrientos, Antonio, Németh, Andrea H, Carelli, Valerio, Huang, Taosheng, Zuchner, Stephan, Dallman, Julia E |
| المصدر: | Nature genetics, vol 47, iss 8 |
| بيانات النشر: | eScholarship, University of California |
| سنة النشر: | 2015 |
| المجموعة: | University of California: eScholarship |
| مصطلحات موضوعية: | COS Cells, Embryo, Nonmammalian, Animals, Genetically Modified, Zebrafish, Humans, Optic Atrophy, Autosomal Dominant, Charcot-Marie-Tooth Disease, Genetic Predisposition to Disease, Phosphate Transport Proteins, Muscle Proteins, Saccharomyces cerevisiae Proteins, Membrane Proteins, Mitochondrial Proteins, Microscopy, Confocal, Electron, Transmission, Pedigree, Sequence Analysis, DNA, RNA Interference, Protein Binding, Mutation, Female, Male, Mitochondrial Membranes, HEK293 Cells |
| جغرافية الموضوع: | 926 - 932 |
| الوصف: | Dominant optic atrophy (DOA) and axonal peripheral neuropathy (Charcot-Marie-Tooth type 2, or CMT2) are hereditary neurodegenerative disorders most commonly caused by mutations in the canonical mitochondrial fusion genes OPA1 and MFN2, respectively. In yeast, homologs of OPA1 (Mgm1) and MFN2 (Fzo1) work in concert with Ugo1, for which no human equivalent has been identified thus far. By whole-exome sequencing of patients with optic atrophy and CMT2, we identified four families with recessive mutations in SLC25A46. We demonstrate that SLC25A46, like Ugo1, is a modified carrier protein that has been recruited to the outer mitochondrial membrane and interacts with the inner membrane remodeling protein mitofilin (Fcj1). Loss of function in cultured cells and in zebrafish unexpectedly leads to increased mitochondrial connectivity, while severely affecting the development and maintenance of neurons in the fish. The discovery of SLC25A46 strengthens the genetic overlap between optic atrophy and CMT2 while exemplifying a new class of modified solute transporters linked to mitochondrial dynamics. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | qt2ft7n3zk; https://escholarship.org/uc/item/2ft7n3zkTest; https://escholarship.org/content/qt2ft7n3zk/qt2ft7n3zk.pdfTest |
| DOI: | 10.1038/ng.3354 |
| الإتاحة: | https://doi.org/10.1038/ng.3354Test https://escholarship.org/uc/item/2ft7n3zkTest https://escholarship.org/content/qt2ft7n3zk/qt2ft7n3zk.pdfTest |
| حقوق: | CC-BY |
| رقم الانضمام: | edsbas.7CAE9228 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ng.3354 |
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