التفاصيل البيبلوغرافية
| العنوان: |
Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy |
| المؤلفون: |
Su, Maureen A, Anderson, Mark S |
| المصدر: |
Cancer Immunology Research, vol 7, iss 6 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2019 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Vaccine Related, Autoimmune Disease, Immunization, Cancer, Biotechnology, Animals, Autoimmune Diseases, Autoimmunity, Central Tolerance, Clonal Deletion, Humans, Immunomodulation, Immunotherapy, Molecular Targeted Therapy, Neoplasms, Organ Specificity, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, T-Lymphocytes, Regulatory, Thymus Gland, Transcription Factors, Pharmacology and Pharmaceutical Sciences |
| جغرافية الموضوع: |
854 - 859 |
| الوصف: |
A major breakthrough in cancer treatment occurred with the development of strategies that overcome T-cell tolerance toward tumor cells. These approaches enhance antitumor immunity by overcoming mechanisms that are normally in place to prevent autoimmunity but simultaneously prevent rejection of tumor cells. Although tolerance mechanisms that restrict antitumor immunity take place both in the thymus and periphery, only immunotherapies that target peripheral tolerance mechanisms occurring outside of the thymus are currently available. We review here recent gains in our understanding of how thymic tolerance mediated by the autoimmune regulator (Aire) impedes antitumor immunity. It is now clear that transient depletion of Aire-expressing cells in the thymus can be achieved with RANKL blockade. Finally, we discuss key findings that support the repurposing of anti-RANKL as a cancer immunotherapy with a unique mechanism of action. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt1980x1bq; https://escholarship.org/uc/item/1980x1bqTest |
| الإتاحة: |
https://escholarship.org/uc/item/1980x1bqTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.E489A79C |
| قاعدة البيانات: |
BASE |
