التفاصيل البيبلوغرافية
| العنوان: |
KIR haplotypes are associated with late-onset type 1 diabetes in European–American families |
| المؤلفون: |
Traherne, JA, Jiang, W, Valdes, AM, Hollenbach, JA, Jayaraman, J, Lane, JA, Johnson, C, Trowsdale, J, Noble, JA |
| المصدر: |
Genes & Immunity, vol 17, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2016 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Immunology, Autoimmune Disease, Clinical Research, Diabetes, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Age of Onset, Child, Diabetes Mellitus, Type 1, Female, Genetic Association Studies, Genetic Predisposition to Disease, HLA Antigens, Haplotypes, Humans, Male, Receptors, KIR, White People |
| جغرافية الموضوع: |
8 - 12 |
| الوصف: |
Classical human leukocyte antigens (HLA) genes confer the strongest, but not the only, genetic susceptibility to type 1 diabetes. Killer cell immunoglobulin-like receptors (KIR), on natural killer (NK) cells, bind ligands including class I HLA. We examined presence or absence, with copy number, of KIR loci in 1698 individuals, from 339 multiplex type 1 diabetes families, from the Human Biological Data Interchange, previously genotyped for HLA. Combining family data with KIR copy number information allowed assignment of haplotypes using identity by descent. This is the first disease study to use KIR copy number typing and unambiguously define haplotypes by gene transmission. KIR A1 haplotypes were positively associated with T1D in the subset of patients without the high T1D risk HLA genotype, DR3/DR4 (odds ratio=1.29, P=0.0096). The data point to a role for KIR in type 1 diabetes risk in late-onset patients. In the top quartile (age of onset>14), KIR A2 haplotype was overtransmitted (63.4%, odds ratio=1.73, P=0.024) and KIR B haplotypes were undertransmitted (41.1%, odds ratio=0.70, P=0.0052) to patients. The data suggest that inhibitory 'A' haplotypes are predisposing and stimulatory 'B' haplotypes confer protection in both DR3/DR4-negative and late-onset patient groups. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3572b5cf; https://escholarship.org/uc/item/3572b5cfTest |
| الإتاحة: |
https://escholarship.org/uc/item/3572b5cfTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.48FF8081 |
| قاعدة البيانات: |
BASE |
