التفاصيل البيبلوغرافية
| العنوان: |
The association of serotonin reuptake inhibitors and benzodiazepines with ictal central apnea |
| المؤلفون: |
Lacuey, Nuria, Martins, Rita, Vilella, Laura, Hampson, Johnson P, Rani, MR Sandhya, Strohl, Kingman, Zaremba, Anita, Hampson, Jaison S, Sainju, Rup K, Friedman, Daniel, Nei, Maromi, Scott, Catherine, Gehlbach, Brian K, Hupp, Norma J, Schuele, Stephan, Ogren, Jennifer, Harper, Ronald M, Allen, Luke, Diehl, Beate, Bateman, Lisa M, Devinsky, Orrin, Richerson, George B, Lhatoo, Samden |
| المصدر: |
Epilepsy & Behavior, vol 98, iss Pt A |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2019 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Brain Disorders, Neurosciences, Clinical Research, Lung, Neurodegenerative, Epilepsy, Neurological, Good Health and Well Being, Adolescent, Adult, Aged, Benzodiazepines, Cohort Studies, Electroencephalography, Female, Humans, Hypoxia, Male, Middle Aged, Oximetry, Prospective Studies, Seizures, Selective Serotonin Reuptake Inhibitors, Sleep Apnea, Central, Sudden Unexpected Death in Epilepsy, Young Adult, SUDEP |
| جغرافية الموضوع: |
73 - 79 |
| الوصف: |
ObjectiveIctal (ICA) and postconvulsive central apnea (PCCA) have been implicated in sudden unexpected death in epilepsy (SUDEP) pathomechanisms. Previous studies suggest that serotonin reuptake inhibitors (SRIs) and benzodiazepines (BZDs) may influence breathing. The aim of this study was to investigate if chronic use of these drugs alters central apnea occurrence in patients with epilepsy.MethodsPatients with epilepsy admitted to epilepsy monitoring units (EMUs) in nine centers participating in a SUDEP study were consented. Polygraphic physiological parameters were analyzed, including video-electroencephalography (VEEG), thoracoabdominal excursions, and pulse oximetry. Outpatient medication details were collected. Patients and seizures were divided into SRI, BZD, and control (no SRI or BZD) groups. Ictal central apnea and PCCA, hypoxemia, and electroclinical features were assessed for each group.ResultsFour hundred and seventy-six seizures were analyzed (204 patients). The relative risk (RR) for ICA in the SRI group was half that of the control group (p = 0.02). In the BZD group, ICA duration was significantly shorter than in the control group (p = 0.02), as was postictal generalized EEG suppression (PGES) duration (p = 0.021). Both SRI and BZD groups were associated with smaller seizure-associated oxygen desaturation (p = 0.009; p ≪ 0.001). Neither presence nor duration of PCCA was significantly associated with SRI or BZD (p ≫ 0.05).ConclusionsSeizures in patients taking SRIs have lower occurrence of ICA, and patients on chronic treatment with BZDs have shorter ICA and PGES durations. Preventing or shortening ICA duration by using SRIs and/or BZD in patients with epilepsy may play a possible role in SUDEP risk reduction. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt56q2p1s9; https://escholarship.org/uc/item/56q2p1s9Test |
| الإتاحة: |
https://escholarship.org/uc/item/56q2p1s9Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.2A761316 |
| قاعدة البيانات: |
BASE |
