التفاصيل البيبلوغرافية
| العنوان: |
Back to the future: mechanism-based, mutation-specific combination chemoprevention with a synthetic lethality approach. |
| المؤلفون: |
Meyskens, Frank L, Jr, Gerner, Eugene W |
| المصدر: |
Cancer prevention research (Philadelphia, Pa.), vol 4, iss 5 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2011 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Apoptosis, Biomimetics, Genes, Lethal, Humans, Intracellular Signaling Peptides and Proteins: antagonists & inhibitors, genetics, Lung Neoplasms: genetics, prevention & control, Mitochondrial Proteins: antagonists & inhibitors, Mutation: genetics, Proto-Oncogene Proteins: antagonists & inhibitors, TNF-Related Apoptosis-Inducing Ligand: antagonists & inhibitors, ras Proteins: antagonists & inhibitors, B Raf kinase inhibitor, eflornithine, imatinib, K ras protein, nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor, retinol acetate, retrovirus vector, second mitochondrial activator of caspase, sulindac, tumor necrosis factor related apoptosis inducing ligand, advanced cancer, breast cancer, carcinogenesis, chemoprophylaxis, colorectal cancer, combination chemotherapy |
| جغرافية الموضوع: |
628 - 632 |
| الوصف: |
There is an increasing recognition that the mutations accompanying carcinogenesis may provide a window of therapeutic advantage designated synthetic lethality, an example of which is reported in this issue of the journal by Huang and colleagues (beginning on page 666). First discovered and studied in yeast, synthetic lethality has basic principles that have encouraged its development for treatment and now prevention in animal models of human cancer, especially malignancies refractory to standard approaches. The pros and cons of this approach and challenges in implementing it clinically are discussed. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt5t1960sp; https://escholarship.org/uc/item/5t1960spTest |
| الإتاحة: |
https://escholarship.org/uc/item/5t1960spTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.31D7D8D9 |
| قاعدة البيانات: |
BASE |
