التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex |
| المؤلفون: |
Shoemake, BM, Ley, BL Vander, Newcomer, BW, Heller, MC |
| المصدر: |
Journal of Veterinary Internal Medicine, vol 32, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Animal Production, Clinical Trials and Supportive Activities, Clinical Research, Infectious Diseases, Prevention, Infection, Administration, Oral, Animals, Bovine Respiratory Disease Complex, Cattle, Herpesvirus 1, Bovine, Hydrogen Peroxide, Iodine, Lactoperoxidase, Mannheimia haemolytica, Nasal Mucosa, Parainfluenza Virus 3, Human, Pasteurellaceae, Sodium Iodide, Hypoiodous acid, Bovine respiratory disease |
| جغرافية الموضوع: |
516 - 524 |
| الوصف: |
BackgroundThe prevention of bovine respiratory disease complex (BRD) in beef cattle is important to maintaining health and productivity of calves in feeding operations.ObjectiveDetermine whether BRD bacterial and viral pathogens are susceptible to the lactoperoxidase/hydrogen peroxide/iodide (LPO/H2 O2 /I- ) system invitro and to determine whether the oral administration of sodium iodide (NaI) could achieve sufficient concentrations of iodine (I) in the respiratory secretions of weaned beef calves to inactivate these pathogens invivo.AnimalsSixteen weaned, apparently healthy, commercial beef calves from the University of Missouri, College of Veterinary Medicine teaching herd.MethodsIn vitro viral and bacterial assays were performed to determine susceptibility to the LPO/H2 O2 /I- system at varying concentrations of NaI. Sixteen randomly selected, healthy crossbred beef weanlings were administered 70mg/kg NaI, or water, orally in a blinded, placebo-controlled trial. Blood and nasal secretions were collected for 72hours and analyzed for I- concentration.ResultsBovine herpesvirus-1, parainfluenza-3, Mannheimia haemolytica and Bibersteinia trehalosi were all inactivated or inhibited invitro by the LPO/H2 O2 /I- reaction. Oral administration of NaI caused a marked increase in nasal fluid I concentration with a Cmax =181 (1,420μM I), T12 , a sufficient concentration to inactivate these pathogens invitro.Conclusions and clinical importanceIn vitro, the LPO/H2 O2 /I- system inactivates and inhibits common pathogens associated with BRD. The administration of oral NaI significantly increases the I concentration of nasal fluid indicating that this system might be useful in preventing bovine respiratory infections. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt91k9d0p6; https://escholarship.org/uc/item/91k9d0p6Test |
| الإتاحة: |
https://escholarship.org/uc/item/91k9d0p6Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.8C8CC96 |
| قاعدة البيانات: |
BASE |
