التفاصيل البيبلوغرافية
| العنوان: |
Cognitive Impairment in Non–Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study |
| المؤلفون: |
Harhay, Meera N, Xie, Dawei, Zhang, Xiaoming, Hsu, Chi-yuan, Vittinghoff, Eric, Go, Alan S, Sozio, Stephen M, Blumenthal, Jacob, Seliger, Stephen, Chen, Jing, Deo, Rajat, Dobre, Mirela, Akkina, Sanjeev, Reese, Peter P, Lash, James P, Yaffe, Kristine, Tamura, Manjula Kurella, Investigators, CRIC Study, Appel, Lawrence J, Feldman, Harold I, He, Jiang, Kusek, John W, Rao, Panduranga, Rahman, Mahboob |
| المصدر: |
American Journal of Kidney Diseases, vol 72, iss 4 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Clinical Research, Kidney Disease, Brain Disorders, Renal and urogenital, Good Health and Well Being, Adult, Age Factors, Aged, Cognitive Behavioral Therapy, Cognitive Dysfunction, Cohort Studies, Disease Progression, Female, Humans, Incidence, Kidney Failure, Chronic, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Predictive Value of Tests, Prognosis, Renal Dialysis, Renal Insufficiency, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Factors |
| جغرافية الموضوع: |
499 - 508 |
| الوصف: |
BACKGROUND:Advanced chronic kidney disease is associated with elevated risk for cognitive impairment. However, it is not known whether and how cognitive impairment is associated with planning and preparation for end-stage renal disease. STUDY DESIGN:Retrospective observational study. SETTING & PARTICIPANTS:630 adults participating in the CRIC (Chronic Renal Insufficiency Cohort) Study who had cognitive assessments in late-stage CKD, defined as estimated glome-rular filtration rate≤ 20mL/min/1.73m2, and subsequently initiated maintenance dialysis therapy. PREDICTOR:Predialysis cognitive impairment, defined as a score on the Modified Mini-Mental State Examination lower than previously derived age-based threshold scores. Covariates included age, race/ethnicity, educational attainment, comorbid conditions, and health literacy. OUTCOMES:Peritoneal dialysis (PD) as first dialysis modality, preemptive permanent access placement, venous catheter avoidance at dialysis therapy initiation, and preemptive wait-listing for a kidney transplant. MEASUREMENTS:Multivariable-adjusted logistic regression. RESULTS:Predialysis cognitive impairment was present in 117 (19%) participants. PD was thefirst dialysis modality among 16% of participants (n=100), 75% had preemptive access placed (n=473), 45% avoided using a venous catheter at dialysis therapy initiation (n=279), and 20%were preemptively wait-listed (n=126).Predialysis cognitive impairment wasindependently associated with 78% lower odds of PD as the first dialysis modality (adjusted OR [aOR], 0.22; 95% CI, 0.06-0.74; P=0.02) and 42% lower odds of venous catheter avoidance at dialysis therapy initiation (aOR, 0.58; 95% CI, 0.34-0.98; P=0.04). Predialysis cognitive impairment was not independently associated with preemptive permanent access placement or wait-listing. LIMITATIONS:Potential unmeasured confounders; single measure of cognitive function. CONCLUSIONS:Predialysis cognitive impairment is associated with a lower likelihood of PD as a first dialysis modality and of ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt9gd7p9k3; https://escholarship.org/uc/item/9gd7p9k3Test |
| الإتاحة: |
https://escholarship.org/uc/item/9gd7p9k3Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.F5DD8FD |
| قاعدة البيانات: |
BASE |
