التفاصيل البيبلوغرافية
| العنوان: |
Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy |
| المؤلفون: |
Bunupuradah, Torsak, Chetchotisakd, Ploenchan, Jirajariyavej, Supunnee, Valcour, Victor, Bowonwattanuwong, Chureeratana, Munsakul, Warangkana, Klinbuayaem, Virat, Prasithsirikul, Wisit, Sophonphan, Jiratchaya, Mahanontharit, Apicha, Hirschel, Bernard, Bhakeecheep, Sorakij, Ruxrungtham, Kiat, Ananworanich, Jintanat, On behalf of the HIV STAR Study Group |
| المصدر: |
Journal of NeuroVirology, vol 18, iss 6 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2012 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Mental Health, Clinical Research, HIV/AIDS, Depression, Brain Disorders, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Adenine, Adult, CD4 Lymphocyte Count, Cognition Disorders, Female, HIV Infections, HIV Protease Inhibitors, HIV-1, Humans, Lamivudine, Lopinavir, Male, Organophosphonates, RNA, Viral, Reverse Transcriptase Inhibitors, Ritonavir, Tenofovir, Viral Load |
| جغرافية الموضوع: |
479 - 487 |
| الوصف: |
We compared rates of neurocognitive impairment (NCI) among 93 Thai adults failing non-nucleoside reverse transcriptase inhibitor (NNRTI)-based combination antiretroviral therapy (cART) before and after switching to lopinavir/ritonavir monotherapy (mLPV/r) vs. tenofovir/lamivudine/LPV/r (TDF/3TC/LPV/r). Participants completed the Color Trails 1 and 2, Digit Symbol, and Grooved Pegboard at weeks 0, 24, and 48. We calculated z-scores using normative data from 451 healthy HIV-negative Thais. We defined NCI as performance of <-1 SD on ≥2 tests. The Thai depression inventory was used to capture depressive symptoms. Lumbar puncture was optional at week 0 and 48. At baseline, median (IQR) age was 36.9 (32.8-40.5) years, and 46 % had primary school education or lower. The median CD4 count was 196 (107-292) cells/mm(3), and plasma HIV RNA was 4.1 (3.6-4.5) log(10) copies/ml. Almost all (97 %) had circulating recombinant CRF01_AE. At baseline, 20 (47 %) of the mLPV/r vs. 22 (44 %) of TDF/3TC/LPV/r arms met NCI criteria (p = 0.89). The frequency of NCI at week 48 was 30 vs. 32 % (p = 0.85) with 6 vs. 7 % (p = 0.85) developing NCI in the mLPV/r vs. TDF/3TC/LPV/r arms, respectively. Having NCI at baseline and lower education each predicted NCI at week 48. Depression scores at week 48 did not differ between arms (p = 0.47). Cerebrospinal fluid HIV RNA of <50 copies/ml at 48 weeks was observed in five out of seven in mLPV/r vs. three out of four in TDF/3TC/LPV/r arm. The rates of NCI and depression did not differ among cases failing NNRTI-based cART who received mLPV/r compared to LPV/r triple therapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
qt1pf2h4ht; https://escholarship.org/uc/item/1pf2h4htTest |
| الإتاحة: |
https://escholarship.org/uc/item/1pf2h4htTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.A50924A0 |
| قاعدة البيانات: |
BASE |
