التفاصيل البيبلوغرافية
| العنوان: |
pH- and thermo-sensitive MTX-loaded magnetic nanocomposites: synthesis, characterization, and in vitro studies on A549 lung cancer cell and MR imaging |
| المؤلفون: |
Farshbaf, Masoud, Salehi, Roya, Annabi, Nasim, Khalilov, Rovshan, Akbarzadeh, Abolfazl, Davaran, Soodabeh |
| المصدر: |
Drug Development and Industrial Pharmacy, vol 44, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Cancer, Biomedical Imaging, Nanotechnology, Bioengineering, A549 Cells, Acrylamides, Cell Line, Tumor, Drug Carriers, Drug Delivery Systems, Humans, Hydrogen-Ion Concentration, Lung Neoplasms, Magnetic Resonance Imaging, Methacrylates, Methotrexate, Nanocomposites, Nanoparticles, Polyethylene Glycols, Polymers, Silicon Dioxide, Theranostic nanomedicine, magnetic nanoparticles, dual-responsive drug delivery, lung cancer, MRI contrast agent, Pharmacology and Pharmaceutical Sciences |
| جغرافية الموضوع: |
452 - 462 |
| الوصف: |
In the current study, we proposed a facile method for fabrication of multifunctional pH- and thermo-sensitive magnetic nanocomposites (MNCs) as a theranostic agent for using in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe3O4 magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo-sensitive properties, respectively. We also conjugated mesoporous silica nanoparticles (MSNs) to polymer matrix acting as drug container to enhance the drug encapsulation efficacy. Methotroxate (MTX) as a model drug was successfully loaded in MNCs (M-MNCs) via surface adsorption onto MSNs and electrostatic interaction between drug and carrier. The pH- and temperature-triggered release of MTX was concluded through the evaluation of in vitro release at both physiological and simulated tumor tissue conditions. Based on in vitro cytotoxicity assay results, M-MNCs significantly revealed higher antitumor activity compared to free MTX. In vitro MR susceptibility experiment showed that M-MNCs relatively possessed high transverse relaxivity (r2) of about 0.15 mM-1·ms-1 and a linear relationship between the transverse relaxation rate (R2) and the Fe concentration in the M-MNCs was also demonstrated. Therefore, the designed MNCs can potentially become smart drug carrier, while they also can be promising MRI negative contrast agent. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt4t38s3t6; https://escholarship.org/uc/item/4t38s3t6Test |
| الإتاحة: |
https://escholarship.org/uc/item/4t38s3t6Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.F3A734C8 |
| قاعدة البيانات: |
BASE |
