التفاصيل البيبلوغرافية
| العنوان: |
Genetic polymorphisms of diabetes‐related genes, their interaction with diabetes status, and breast cancer incidence and mortality: The Long Island Breast Cancer Study Project |
| المؤلفون: |
Parada, Humberto, Cleveland, Rebecca J, North, Kari E, Stevens, June, Teitelbaum, Susan L, Neugut, Alfred I, Santella, Regina M, Martinez, Maria E, Gammon, Marilie D |
| المصدر: |
Molecular Carcinogenesis, vol 58, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2019 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Aging, Diabetes, Human Genome, Cancer, Genetics, Prevention, Breast Cancer, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Adult, Aged, 80 and over, Biomarkers, Breast Neoplasms, Case-Control Studies, Diabetes Mellitus, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Incidence, Middle Aged, Polymorphism, Single Nucleotide, Prognosis, Survival Rate, Young Adult |
| جغرافية الموضوع: |
436 - 446 |
| الوصف: |
To examine 143 diabetes risk single nucleotide polymorphisms (SNPs), identified from genome-wide association studies, in association with breast cancer (BC) incidence and subsequent mortality. A population-based sample of Caucasian women with first primary invasive BC (n = 817) and controls (n = 1021) were interviewed to assess diabetes status. Using the National Death Index, women with BC were followed for >18 years during which 340 deaths occurred (139 BC deaths). Genotyping was done using DNA extracted from blood samples. We used unconditional logistic regression to estimate age-adjusted odds ratios and 95% confidence intervals (CIs) for BC incidence, and Cox regression to estimate age-adjusted hazard ratios and CIs for all-cause and BC-specific mortality. Twelve SNPs were associated with BC risk in additive genotype models, at α = 0.05. The top three significant SNPs included SLC30A8-rs4876369 (P = 0.0034), HHEX-rs11187146 (P = 0.0086), and CDKN2A/CDKN2B-rs1333049 (P = 0.0094). Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. Six SNPs were associated with all-cause (CDKAL1-rs981042, P = 0.0032; HHEX-rs1111875, P = 0.0361; and INSR-rs919275, P = 0.0488) or BC-specific (CDKN2A/CDKN2B-rs3218020, P = 0.0225; CDKAL1-rs981042, P = 0.0246; and TCF2/HNF1B-rs3094508, P = 0.0344) mortality in additive genotype models, at α = 0.05. Genetic polymorphisms that increase the risk of developing diabetes may also increase the risk of developing and dying from BC. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3jd483j9; https://escholarship.org/uc/item/3jd483j9Test |
| الإتاحة: |
https://escholarship.org/uc/item/3jd483j9Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.1213F27E |
| قاعدة البيانات: |
BASE |
