دورية أكاديمية

Sodium–glucose co‐transporter 2 inhibitors as an early, first‐line therapy in patients with heart failure and reduced ejection fraction

التفاصيل البيبلوغرافية
العنوان: Sodium–glucose co‐transporter 2 inhibitors as an early, first‐line therapy in patients with heart failure and reduced ejection fraction
المؤلفون: Tomasoni, Daniela, Fonarow, Gregg C, Adamo, Marianna, Anker, Stefan D, Butler, Javed, Coats, Andrew JS, Filippatos, Gerasimos, Greene, Stephen J, McDonagh, Theresa A, Ponikowski, Piotr, Rosano, Giuseppe, Seferovic, Petar, Vaduganathan, Muthiah, Voors, Adriaan A, Metra, Marco
المصدر: European Journal of Heart Failure, vol 24, iss 3
بيانات النشر: eScholarship, University of California
سنة النشر: 2022
المجموعة: University of California: eScholarship
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Diabetes, Cardiovascular, Heart Disease, Clinical Research, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Development of treatments and therapeutic interventions, Metabolic and endocrine, Good Health and Well Being, Diabetes Mellitus, Type 2, Glucose, Heart Failure, Humans, Quality of Life, Sodium, Sodium-Glucose Transporter 2 Inhibitors, Stroke Volume, Symporters, Heart failure with reduced ejection fraction, Sodium-glucose co-transporter 2 inhibitors, Dapagliflozin, Empagliflozin, Sotagliflozin, Medical therapy, Cardiorespiratory Medicine and Haematology
جغرافية الموضوع: 431 - 441
الوصف: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have recently been recommended as a foundational therapy for patients with heart failure (HF) and reduced ejection fraction (HFrEF) because of their favourable effects on mortality, clinical events and quality of life. While clinical practice guidelines have recommended dapagliflozin or empagliflozin in all patients with HFrEF, or sotagliflozin in those with HFrEF and concomitant diabetes, the timing and practical integration of these drugs in clinical practice is less well defined. We propose that these drugs are candidates for early, upfront administration to patients with newly diagnosed HFrEF and for patients hospitalized with HF. Growing evidence has established early benefits, with clinically meaningful reductions in clinical events that reach statistical significance within days to weeks, following dapagliflozin, empagliflozin or, in diabetic patients, sotagliflozin initiation. Secondly, although major clinical trials have tested these drugs in patients already receiving background HF therapy, secondary analyses showed that their efficacy is independent of that. Third, SGLT2 inhibitors are generally safe and well tolerated, with clinical trial data reporting minimal effects on blood pressure, glycaemia-related adverse events, and no excess in acute kidney injury. Rather, they exert renal protective effects and reduce risk of hyperkalaemia, properties that favour initiation, tolerance and persistence of renin-angiotensin system inhibitors and mineralocorticoid receptor antagonists. This review supports the early initiation of dapagliflozin and empagliflozin (or sotagliflozin limited to patients with diabetes) to rapidly improve clinical outcome and quality of life of HFrEF patients.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: unknown
العلاقة: qt2r92q7r4; https://escholarship.org/uc/item/2r92q7r4Test
الإتاحة: https://escholarship.org/uc/item/2r92q7r4Test
حقوق: public
رقم الانضمام: edsbas.A867954F
قاعدة البيانات: BASE