التفاصيل البيبلوغرافية
| العنوان: |
Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer |
| المؤلفون: |
Cascone, Tina, Gold, Kathryn A, Swisher, Stephen G, Liu, Diane D, Fossella, Frank V, Sepesi, Boris, Pataer, Apar, Weissferdt, Annikka, Kalhor, Neda, Vaporciyan, Ara A, Hofstetter, Wayne L, Wistuba, Ignacio I, Heymach, John V, Kim, Edward S, William, William N |
| المصدر: |
The Annals of Thoracic Surgery, vol 105, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Patient Safety, Lung, Lung Cancer, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, 80 and over, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Chemotherapy, Adjuvant, Cisplatin, Docetaxel, Dose-Response Relationship, Drug, Drug Therapy, Combination, Erlotinib Hydrochloride, Female, Follow-Up Studies, Humans, Induction Chemotherapy, Lung Neoplasms |
| جغرافية الموضوع: |
418 - 424 |
| الوصف: |
BackgroundData from meta-analyses support the use of induction or adjuvant platinum-based chemotherapy for locally advanced non-small cell lung cancers (NSCLCs). This phase 2 study assessed the role of induction cisplatin and docetaxel followed by surgery in patients with resectable stage I to III NSCLCs, followed by 12 months of adjuvant erlotinib.MethodsPatients with resectable stage I to III NSCLCs received cisplatin 80 mg/m2, docetaxel 75 mg/m2 every 21 days for 3 cycles, followed by surgery, followed by adjuvant erlotinib for 12 months. The primary endpoint included safety. Long-term efficacy outcomes and exploratory analysis of intermediary endpoints are also reported (NCT00254384).ResultsForty-seven eligible patients received a median of 3 cycles of induction treatment, 37 underwent surgical resection, and only 21 received adjuvant erlotinib. Two patients died in the perioperative period (1 sepsis during chemotherapy, 1 acute respiratory distress syndrome postoperatively). Most common grade 3 to 5 toxicities during chemotherapy included hypokalemia (8%), infection (7%), and granulocytopenia (25%). During adjuvant erlotinib, 14% of patients experienced grade 2 rash. Median overall survival was 3.4 years. Major pathologic responses in the primary tumor were observed in 19% (7 of 37) of patients and correlated with improved long-term overall survival. Complete pathologic response in mediastinal/hilar nodes also correlated with superior survival.ConclusionsInduction cisplatin and docetaxel was well tolerated. Adjuvant erlotinib did not improve outcomes compared with historical controls. Major pathologic response predicted for improved long-term survival and is a suitable intermediary endpoint for future phase 2studies. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt8kv987pm; https://escholarship.org/uc/item/8kv987pmTest |
| الإتاحة: |
https://escholarship.org/uc/item/8kv987pmTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.84A24557 |
| قاعدة البيانات: |
BASE |
