التفاصيل البيبلوغرافية
| العنوان: |
Co-localization of corticotropin-releasing hormone with glutamate decarboxylase and calcium-binding proteins in infant rat neocortical interneurons |
| المؤلفون: |
Yan, Xiao-Xin, Baram, Tallie Z, Gerth, Angelika, Schultz, Linda, Ribak, CE |
| المصدر: |
Experimental Brain Research, vol 123, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
1998 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Mental Health, Brain Disorders, Animals, Newborn, Calbindin 2, Calbindins, Calcium-Binding Proteins, Corticotropin-Releasing Hormone, Glutamate Decarboxylase, Immunohistochemistry, Interneurons, Neocortex, Nerve Tissue Proteins, Parvalbumins, Rats, Sprague-Dawley, S100 Calcium Binding Protein G, neuropeptides, parvalbumin, GABA, cerebral cortex, basket cells, chandelier cells, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery |
| جغرافية الموضوع: |
334 - 340 |
| الوصف: |
Corticotropin releasing hormone (CRH) has been localized to interneurons of the mammalian cerebral cortex, but these neurons have not been fully characterized. The present study determined the extent of co-localization of CRH with glutamate decarboxylase (GAD) and calcium-binding proteins in the infant rat neocortex using immunocytochemistry. CRH-immunoreactive (ir) neurons were classified into two major groups. The first group was larger and consisted of densely CRH-immunostained small bipolar cells, predominantly localized to layers II and III. The second group of CRH-ir cells was lightly labeled and included multipolar neurons mainly found in deep cortical layers. Co-localization studies indicated that the vast majority of CRH-ir neurons, including both bipolar and multipolar types, was co-immunolabeled for GAD-65 and GAD-67. Most multipolar, but only some bipolar, CRH-ir neurons also contained parvalbumin, while CRH-ir neurons rarely contained calbindin or calretinin. These results indicate that virtually all CRH-ir neurons in the rat cerebral cortex are GABAergic. Furthermore, since parvalbumin is expressed by cortical basket and chandelier cells, the co-localization of CRH and parvalbumin suggests that some cortical CRH-ir neurons may belong to these two cell types. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt0tr20290; https://escholarship.org/uc/item/0tr20290Test |
| الإتاحة: |
https://escholarship.org/uc/item/0tr20290Test |
| حقوق: |
CC-BY |
| رقم الانضمام: |
edsbas.DD8EF2C3 |
| قاعدة البيانات: |
BASE |
