التفاصيل البيبلوغرافية
| العنوان: |
Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA |
| المؤلفون: |
Jacobson, Jeffrey M, Routy, Jean-Pierre, Welles, Seth, DeBenedette, Mark, Tcherepanova, Irina, Angel, Jonathan B, Asmuth, David M, Stein, David K, Baril, Jean-Guy, McKellar, Mehri, Margolis, David M, Trottier, Benoit, Wood, Kenneth, Nicolette, Charles |
| المصدر: |
JAIDS Journal of Acquired Immune Deficiency Syndromes, vol 72, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2016 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Infectious Diseases, HIV/AIDS, Immunization, Vaccine Related, Clinical Trials and Supportive Activities, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Good Health and Well Being, Adolescent, Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Dendritic Cells, Double-Blind Method, Female, Granzymes, HIV Infections, HIV-1, Humans, Immunotherapy, Interferon-gamma, Interleukin-2, Lysosomal-Associated Membrane Protein 1, Male, Middle Aged, Placebos, RNA, Viral |
| جغرافية الموضوع: |
31 - 38 |
| الوصف: |
BackgroundThe genomic heterogeneity of HIV-1 impedes the ability of consensus sequences in vaccines to elicit effective antiviral immune responses. AGS-004 amplifies translation-competent RNA molecules encoding for Gag, Rev, Vpr, and Nef from the patient's autologous virus and loads them into dendritic cells.MethodsThis phase IIB, multicenter, 2:1 randomized, double-blind, placebo-controlled study enrolled 54 HIV-1-infected patients on antiretroviral therapy with viral loads (VLs) <50 copies per milliliter, current CD4 T-cell counts >450 cells per cubic millimeter, and nadir counts >200 cells per cubic millimeter, to receive intradermal injections of study product into the axillary lymph node region every 4 weeks. At week 16, a 12-week analytical treatment interruption (ATI) was undertaken.ResultsThere was no difference in the end-of-ATI VL (average of values from weeks 11 and 12) between the 2 arms of the study [4.39 (4.17, 4.69) vs. 4.47 (3.76, 4.64) log10 HIV-1 RNA; P = 0.73]. Between arms, no change between pre-antiretroviral therapy VL and the end-of-ATI VL [-0.06 (0.24, -0.32) vs. -0.17 (0.17, -0.32) log10 HIV-1 RNA; P = 0.43] was observed. When interferon-γ, interleukin-2, tumor necrosis factor α, CD107a, and granzyme b expressions were measured by multicolor flow cytometry, a greater percentage of AGS-004 than of placebo recipients had multifunctional cytotoxic T-lymphocyte responses induced in the CD28+/CD45RA-CD8 effector/memory T-cell population to dendritic cells electroporated with autologous antigens. Adverse events consisted of transient, mild (grade 1) local injection site reactions.ConclusionsDespite the induction of HIV-specific effector/memory CD8 T-cell responses, no antiviral effect was seen after the administration of AGS-004 when compared with placebo. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt1085x55b; https://escholarship.org/uc/item/1085x55bTest |
| الإتاحة: |
https://escholarship.org/uc/item/1085x55bTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.CFBC4FAE |
| قاعدة البيانات: |
BASE |
