التفاصيل البيبلوغرافية
| العنوان: |
Early Predictors of Poor Neurologic Outcomes in a Prospective Cohort of Infants With Antenatal Exposure to Zika Virus |
| المؤلفون: |
Tiene, Sophia Finn, Cranston, Jessica S, Nielsen-Saines, Karin, Kerin, Tara, Fuller, Trevon, Vasconcelos, Zilton, Marschik, Peter B, Zhang, Dajie, Pone, Marcos, Pone, Sheila, Zin, Andrea, Brickley, Elizabeth, Orofino, Dulce, Brasil, Patricia, Adachi, Kristina, da Costa, Ana Carolina C, Moreira, Maria Elisabeth Lopes |
| المصدر: |
The Pediatric Infectious Disease Journal, vol 41, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2022 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Paediatrics, Biomedical and Clinical Sciences, Prevention, Neurosciences, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Good Health and Well Being, Brazil, Child, Preschool, Cohort Studies, Female, Humans, Infant, Language Development Disorders, Microcephaly, Nervous System, Pregnancy, Pregnancy Complications, Infectious, Prospective Studies, Zika Virus, Zika Virus Infection, neurodevelopment |
| جغرافية الموضوع: |
255 - 262 |
| الوصف: |
BackgroundIdentify early predictors of poor neurodevelopment in infants with antenatal Zika virus (ZIKV) exposure.MethodsAnalysis of a prospective cohort of infants with antenatal ZIKV exposure confirmed by maternal or infant RT-PCR or IgM during the epidemic in Rio de Janeiro, Brazil. Clinical findings before 3 months of age were associated with Bayley-III Scales of Infant and Toddler Development conducted after 6 months of age.ResultsZIKV exposure was confirmed in 219 cases; 162 infants were normocephalic, 53 were microcephalic, 4 had no head circumference recorded because of perinatal death/LTFU. Seven of the 112 normocephalic infants developed secondary microcephaly between 3 weeks and 8 months of age. Among the normocephalic at birth cohort, the mean HCZ among normal, at risk, and developmentally delayed children was significantly different (ANOVA, P = 0.02). In particular, the mean HCZ of the developmentally delayed group was significantly lower than that of the normal group (Tukey's test, P = 0.014). HCZ was more strongly associated with lower expressive language scores (P = 0.04) than receptive language scores (P = 0.06). The rate of auditory abnormalities differed among the normal, at risk, and developmentally delayed groups (Chi-squared test, P = 0.016), which was driven by the significant difference between the normal and at risk groups (post hoc test, P = 0.011, risk ratio 3.94). Auditory abnormalities were associated with both expressive and receptive language delays (P = 0.02 and P = 0.02, respectively).ConclusionsClear predictors of neurodevelopment in normocephalic ZIKV-exposed children have not been previously identified. Our findings demonstrate that smaller HCZ and auditory abnormalities in these infants correlate with poor neurodevelopment as toddlers. Language delay is the most prominent developmental concern among these children, who will require frequent auditory and speech evaluations throughout childhood. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt60g996n4; https://escholarship.org/uc/item/60g996n4Test |
| الإتاحة: |
https://escholarship.org/uc/item/60g996n4Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.7F8E0CB |
| قاعدة البيانات: |
BASE |
