التفاصيل البيبلوغرافية
| العنوان: |
A conceptual model for the development process of confirmatory adaptive clinical trials within an emergency research network |
| المؤلفون: |
Mawocha, Samkeliso C, Fetters, Michael D, Legocki, Laurie J, Guetterman, Timothy C, Frederiksen, Shirley, Barsan, William G, Lewis, Roger J, Berry, Donald A, Meurer, William J |
| المصدر: |
Clinical Trials, vol 14, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2017 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Clinical Trials and Supportive Activities, Adaptive Clinical Trials as Topic, Biomedical Research, Communication, Cooperative Behavior, Humans, Models, Statistical, Qualitative Research, Research Design, Surveys and Questionnaires, Adaptive clinical trials, confirmatory-phase clinical trials, mixed methods, Strength-Weaknesses-Opportunities-Threats, neurology clinical trials, Strength–Weaknesses–Opportunities–Threats, Statistics, Statistics & Probability, Clinical and health psychology |
| جغرافية الموضوع: |
246 - 254 |
| الوصف: |
BackgroundAdaptive clinical trials use accumulating data from enrolled subjects to alter trial conduct in pre-specified ways based on quantitative decision rules. In this research, we sought to characterize the perspectives of key stakeholders during the development process of confirmatory-phase adaptive clinical trials within an emergency clinical trials network and to build a model to guide future development of adaptive clinical trials.MethodsWe used an ethnographic, qualitative approach to evaluate key stakeholders' views about the adaptive clinical trial development process. Stakeholders participated in a series of multidisciplinary meetings during the development of five adaptive clinical trials and completed a Strengths-Weaknesses-Opportunities-Threats questionnaire. In the analysis, we elucidated overarching themes across the stakeholders' responses to develop a conceptual model.ResultsFour major overarching themes emerged during the analysis of stakeholders' responses to questioning: the perceived statistical complexity of adaptive clinical trials and the roles of collaboration, communication, and time during the development process. Frequent and open communication and collaboration were viewed by stakeholders as critical during the development process, as were the careful management of time and logistical issues related to the complexity of planning adaptive clinical trials.ConclusionThe Adaptive Design Development Model illustrates how statistical complexity, time, communication, and collaboration are moderating factors in the adaptive design development process. The intensity and iterative nature of this process underscores the need for funding mechanisms for the development of novel trial proposals in academic settings. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt0858n495; https://escholarship.org/uc/item/0858n495Test |
| الإتاحة: |
https://escholarship.org/uc/item/0858n495Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.59FD3F17 |
| قاعدة البيانات: |
BASE |
