التفاصيل البيبلوغرافية
| العنوان: |
Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses |
| المؤلفون: |
Greaney, Samantha K, Algazi, Alain P, Tsai, Katy K, Takamura, Kathryn T, Chen, Lawrence, Twitty, Christopher G, Zhang, Li, Paciorek, Alan, Pierce, Robert H, Le, Mai H, Daud, Adil I, Fong, Lawrence |
| المصدر: |
Cancer Immunology Research, vol 8, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Clinical Trials and Supportive Activities, Cancer, Clinical Research, Inflammatory and immune system, Adjuvants, Immunologic, Antigens, Neoplasm, Biomarkers, CD8-Positive T-Lymphocytes, Electroporation, Humans, Immunity, Cellular, Immunotherapy, Interferon-gamma, Interleukin-12, Melanoma, Neoplasm Staging, Patient Safety, Plasmids, Skin Neoplasms, Treatment Outcome, Tumor Microenvironment, Immunology, Oncology and Carcinogenesis, Pharmacology and Pharmaceutical Sciences |
| جغرافية الموضوع: |
246 - 254 |
| الوصف: |
Whereas systemic IL12 is associated with potentially life-threatening toxicity, intratumoral delivery of IL12 through tavokinogene telseplasmid electroporation (tavo) is safe and can induce tumor regression at distant sites. The mechanism by which these responses are mediated is unknown but is presumed to result from a cellular immune response. In a phase II clinical trial of tavo (NCT01502293), samples from 29 patients with cutaneous melanoma with in-transit disease were assessed for immune responses induced with this treatment. Within the blood circulating immune cell population, we found that the frequencies of circulating PD-1+ CD4+ and CD8+ T cells declined with treatment. Circulating immune responses to gp100 were also detected following treatment as measured by IFNγ ELISpot. Patients with a greater antigen-specific circulating immune response also had higher numbers of CD8+ T cells within the tumor. Clinical response was also associated with increased intratumoral CD3+ T cells. Finally, intratumoral T-cell clonality and convergence were increased after treatment, indicating a focusing of the T-cell receptor repertoire. These results indicated that local treatment with tavo can induce a systemic T-cell response and recruit T cells to the tumor microenvironment. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt28b0z9wr; https://escholarship.org/uc/item/28b0z9wrTest |
| الإتاحة: |
https://escholarship.org/uc/item/28b0z9wrTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.6BC2AEC7 |
| قاعدة البيانات: |
BASE |
