التفاصيل البيبلوغرافية
| العنوان: |
Molecular restrictions for human eye irritation by chemical vapors |
| المؤلفون: |
Cometto-Muniz, J. Enrique, Cain, William S., Abraham, Michael H. |
| المصدر: |
Toxicology and Applied Pharmacology, vol 207 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2005 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
eye irritation, ocular chemesthesis, trigeminal nerve, chemical irritation cut-off, homologous acetates, homologous n-alcohols, chemosensory structure-activity |
| جغرافية الموضوع: |
232 - 243 |
| الوصف: |
Previous research showed a cut-off along homologous volatile organic compounds (VOCs) in their ability to produce acute human mucosal irritation. The present study sought to specify the particular cut-off homolog for sensory eye irritation in an acetate and n-alcohol series. A 1,900 ml glass vessel system and a three-alternative forced-choice procedure served to test nonyl, decyl, and dodecyl acetate, and 1-nonanol, 1-decanol, and 1-undecanol. Flowrate to the eye ranged from 2 to 8 L/min and time of exposure from 3 to 24 sec. Decyl acetate and 1-undecanol were the shortest homologs that failed to produce eye irritation under all conditions, producing a cut-off effect. Increasing the vapor concentration of decyl acetate and 1-undecanol by 3 and 8 times, respectively, via heating them to 37 °C made either or both VOCs detectable to only half of the 12 subjects tested, even though the higher vapor concentration was well above a predicted eye irritation threshold. When eye irritation thresholds for homologous acetates and n-alcohols were plotted as a function of the longest unfolded length of the molecule, the values for decyl acetate and 1-undecanol fell within a restricted range of 18 to 19 Å. The outcome suggests that the basis for the cut-off is biological, i.e., the molecule lacks a key size or structure to trigger transduction, rather than physical, i.e., the vapor concentration is too low to precipitate detection. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt7c15904d; https://escholarship.org/uc/item/7c15904dTest |
| الإتاحة: |
https://escholarship.org/uc/item/7c15904dTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.E9FA8D0C |
| قاعدة البيانات: |
BASE |
