التفاصيل البيبلوغرافية
| العنوان: |
Early liver transplantation for severe alcoholic hepatitis |
| المؤلفون: |
Lee, Brian P, Terrault, Norah A |
| المصدر: |
Current Opinion in Organ Transplantation, vol 23, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Infectious Diseases, Hepatitis, Alcoholism, Alcohol Use and Health, Chronic Liver Disease and Cirrhosis, Organ Transplantation, Clinical Research, Clinical Trials and Supportive Activities, Transplantation, Liver Disease, Substance Misuse, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Oral and gastrointestinal, Good Health and Well Being, Alcohol Abstinence, Alcohol Drinking, Consensus, Alcoholic, Humans, Liver Transplantation, Severity of Illness Index, United States, alcohol use disorder, early, recidivism, relapse |
| جغرافية الموضوع: |
229 - 236 |
| الوصف: |
Purpose of reviewAlcohol-related liver disease is now the most common indication for liver transplant in the United States. Acute alcoholic hepatitis represents a subpopulation with short-term mortality approaching 70% in severe cases - these patients are not typically eligible for liver transplant, as most centers require a period of alcohol abstinence (typically 6 months) prior to transplant. Early liver transplant (prior to a requisite period of abstinence) is being increasingly offered in a minority of U.S. centers. The present review examines clinical and ethical considerations surrounding liver transplant for severe alcoholic hepatitis, key published studies and knowledge gaps, and future directions for clinical research to achieve optimal patient outcomes.Recent findingsSince a European pilot study published in 2011, published U.S. original studies in early liver transplantation for severe alcoholic hepatitis are limited to 1 UNOS review, and 2 retrospective single-center studies. A preliminary report from the ACCELERATE-AH consortium show short-term outcomes are acceptable and that use of alcohol posttransplant occurs in 25% of patients. These studies confirm the survival benefit of early liver transplant for alcoholic hepatitis and report rates of alcohol use posttransplant similar to historic cohorts in alcohol-related cirrhosis.SummaryEarly liver transplantation for severe alcoholic hepatitis is lifesaving, with acceptable short to intermediate-term patient survival and rates of alcohol use posttransplant. Further study is needed to determine long-term outcomes, and how best to select and manage patients for this new indication for liver transplant. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt7rc8q78j; https://escholarship.org/uc/item/7rc8q78jTest |
| الإتاحة: |
https://escholarship.org/uc/item/7rc8q78jTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.81677367 |
| قاعدة البيانات: |
BASE |
