التفاصيل البيبلوغرافية
| العنوان: |
Spontaneous loss of surface antigen among adults living with chronic hepatitis B virus infection: a systematic review and pooled meta-analyses |
| المؤلفون: |
Zhou, Kali, Contag, Caitlin, Whitaker, Evans, Terrault, Norah |
| المصدر: |
The Lancet Gastroenterology & Hepatology, vol 4, iss J Viral Hepat 19 2012 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2019 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Hepatitis - B, Digestive Diseases, Infectious Diseases, Chronic Liver Disease and Cirrhosis, Hepatitis, Liver Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Adult, Antigens, Surface, Female, Follow-Up Studies, Hepatitis B Surface Antigens, Hepatitis B virus, Hepatitis B, Chronic, Humans, Male, Middle Aged, Observational Studies as Topic, Prevalence, Prospective Studies, Retrospective Studies |
| جغرافية الموضوع: |
227 - 238 |
| الوصف: |
BackgroundSpontaneous loss of HBsAg (known as functional cure) in patients with chronic hepatitis B virus (HBV) infection significantly reduces liver-related complications. HBsAg loss has been suggested to be higher in non-endemic regions than in endemic regions in individual studies. We systematically determined a pooled annual rate of HBsAg loss in adults with untreated chronic HBV infection and examined the effect of regional endemicity.MethodsIn this systematic review and meta-analysis, we searched PubMed and Embase for observational cohort studies and non-treatment arms of randomised controlled trials reporting proportions of patients with chronic HBV infection that achieved spontaneous HBsAg loss, published up to Oct 1, 2018. We excluded randomised controlled trials from meta-analyses because of substantial cohort differences. Two reviewers (KZ and CC) independently extracted data from accepted full-text studies, with discrepancies discussed with a third reviewer (NT). We assessed rate of HBsAg loss, and stratified results by whether the underlying cohort arose primarily from an endemic region (defined as having prevalence of chronic HBV greater than 2%) or non-endemic region. This study is registered with PROSPERO, number CRD42018074086.FindingsOf 5186 studies screened, 67 (11 randomised controlled trials, 39 prospective and 17 retrospective cohort studies) met the inclusion criteria and 56 were included in meta-analyses after exclusion of randomised controlled trials. Spontaneous HBsAg loss occurred in 3837 (7·8%) of 48 972 patients, with cumulative 352 381 person-years of follow-up. The pooled annual incidence of HBsAg loss was 1·17% (95% CI 0·94-1·41, I2=97%). Rates did not differ by endemicity: 1·19% (0·88-1·54) in endemic versus 1·29% (0·99-1·62) in non-endemic cohorts.InterpretationGlobally, spontaneous HBsAg loss occurs infrequently (about 1% per year) in treatment-naive adults with chronic HBV infection. The low and homogeneous rate of HBsAg loss highlights the need for new therapeutics aimed at ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt5gj7p47q; https://escholarship.org/uc/item/5gj7p47qTest |
| الإتاحة: |
https://escholarship.org/uc/item/5gj7p47qTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.E4FC0D75 |
| قاعدة البيانات: |
BASE |
