التفاصيل البيبلوغرافية
| العنوان: |
Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation |
| المؤلفون: |
Liao, X Charlene, Fournier, Sylvie, Killeen, Nigel, Weiss, Arthur, Allison, James P, Littman, Dan R |
| المصدر: |
Journal of Experimental Medicine, vol 186, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
1997 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Immunology, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Aetiology, Underpinning research, Inflammatory and immune system, Animals, CD28 Antigens, Interleukin-2, Lymphocyte Activation, Mice, Inbred C57BL, Protein-Tyrosine Kinases, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Medical and Health Sciences, Health sciences |
| جغرافية الموضوع: |
221 - 228 |
| الوصف: |
CD28 is a cell surface molecule that mediates a costimulatory signal crucial for T cell proliferation and lymphokine production. The signal transduction mechanisms of CD28 are not well understood. Itk, a nonreceptor protein tyrosine kinase specifically expressed in T cells and mast cells, has been implicated in the CD28 signaling pathway because of reports that it becomes phosphorylated on tyrosines and associates with CD28 upon cross-linking of the cell surface molecule. To determine whether Itk plays a functional role in CD28 signaling, we compared T cells from Itk-deficient mice and control mice for their responses to CD28 costimulation. T cells defective in Itk were found to be fully competent to respond to costimulation. Whereas the CD3-mediated proliferative response was severely compromised in the absence of Itk, the calcineurin-independent CD28-mediated response was significantly elevated when compared with cells from control animals. The augmented proliferation was not due to increased production of interleukin-2. The results suggest that Itk has distinct roles in the CD3 versus the CD28 signaling pathways. By negatively regulating the amplitude of signaling upon CD28 costimulation, Itk may provide a means for modulating the outcome of T cell activation during development and during antigen-driven immune responses. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt2372996n; https://escholarship.org/uc/item/2372996nTest |
| الإتاحة: |
https://escholarship.org/uc/item/2372996nTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.3B84E5C1 |
| قاعدة البيانات: |
BASE |
