التفاصيل البيبلوغرافية
| العنوان: |
Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells |
| المؤلفون: |
O'Donnell, Hope, Pham, Oanh H, Li, Lin-xi, Atif, Shaikh M, Lee, Seung-Joo, Ravesloot, Marietta M, Stolfi, Jessica L, Nuccio, Sean-Paul, Broz, Petr, Monack, Denise M, Baumler, Andreas J, McSorley, Stephen J |
| المصدر: |
Immunity, vol 40, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2014 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Immunology, Emerging Infectious Diseases, Vaccine Related, Infectious Diseases, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Infection, Animals, Bacterial Load, CD4 Antigens, Chlamydia, Flow Cytometry, Immunity, Innate, Inflammasomes, Interleukin-18, Mice, Inbred C57BL, Real-Time Polymerase Chain Reaction, Salmonella, Signal Transduction, Th1 Cells, Toll-Like Receptor 4, Toll-Like Receptors |
| جغرافية الموضوع: |
213 - 224 |
| الوصف: |
T cell effector functions can be elicited by noncognate stimuli, but the mechanism and contribution of this pathway to the resolution of intracellular macrophage infections have not been defined. Here, we show that CD4(+) T helper 1 (Th1) cells could be rapidly stimulated by microbe-associated molecular patterns during active infection with Salmonella or Chlamydia. Further, maximal stimulation of Th1 cells by lipopolysaccharide (LPS) did not require T-cell-intrinsic expression of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), or interferon-γ receptor (IFN-γR) but instead required IL-18R, IL-33R, and adaptor protein MyD88. Innate stimulation of Th1 cells also required host expression of TLR4 and inflammasome components that together increased serum concentrations of IL-18. Finally, the elimination of noncognate Th1 cell stimulation hindered the resolution of primary Salmonella infection. Thus, the in vivo bactericidal capacity of Th1 cells is regulated by the response to noncognate stimuli elicited by multiple innate immune receptors. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3cb280fx; https://escholarship.org/uc/item/3cb280fxTest |
| الإتاحة: |
https://escholarship.org/uc/item/3cb280fxTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.71BA2143 |
| قاعدة البيانات: |
BASE |
